Prostatic cancer, acid phosphatase, creatine, kinase-BB and race: A prospective study

W. R. Fair, W. D W Heston, D. Kadmon, D. B. Crane, W. J. Catalona, J. H. Ladenson, J. M. McDonald, B. W. Noll, G. Harvey

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

To examine the effectiveness of prostatic acid phosphatase and creatine kinase-BB determinations in detecting prostatic cancer serum from 594 men more than 40 years old was assayed for prostatic acid phosphatase with the thymolphthalein monophosphate substrate and a radioimmunoassay kit. Creatine kinase-BB levels also were measured with a radioimmunoassay kit. Patients with benign prostatic hyperplasia had higher prostatic acid phosphatase levels than normal controls. Accordingly, to avoid a high incidence of false positives in patients with benign prostatic hyperplasia the 92.5 percentile level of the patients with benign prostatic hyperplasia (3.9 ng/ml) was chosen as the upper limit of normal. With this critical value elevated prostatic acid phosphatase levels were observed in 6% of the patients with clinical stage A disease, 8% with stage B, 35% with stage C and 68% with stage D. The radioimmunoassay was no more effective than the enzymatic assay in detecting prostatic cancer. A correlation between prostatic acid phosphatase levels and patient race was observed, with 80% of the black patients with extracapsular prostatic cancer having elevated prostatic acid phosphatase levels compared to 34% of the white patients with similar stage disease. Creatine kinase-BB was elevated only in patients with advanced disease and was of little value in the diagnosis of prostatic cancer.

Original languageEnglish (US)
Pages (from-to)735-738
Number of pages4
JournalUnknown Journal
Volume128
Issue number4
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Urology

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