Protease nexin I immunostaining in alzheimer's disease

Dorrie E. Rosenblatt*, Changiz Geula, M‐Marsel ‐M Mesulam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Immunohistochemical experiments showed that a small subset of neuritic plaques in brains affected by Alzheimer's disease stain positively with an antibody to the protease inhibitor protease nexin I. Nearly all plaques and tangles throughout the brain also showed a heightened avidity for a protease nexin I antibody‐antigen aggregate, suggesting that plaques and tangles may have a particularly high density of protease nexin I–binding sites. These observations provide further evidence for a potential disruption of protein processing in the brains of patients with Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)628-634
Number of pages7
JournalAnnals of neurology
Volume26
Issue number5
DOIs
StatePublished - Nov 1989

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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