Proteasomal regulation of nuclear receptor corepressor-mediated repression

Jinsong Zhang, Matthew G. Guenther, Richard W. Carthew, Mitchell A. Lazar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

189 Scopus citations


Repression of gene transcription is a fundamental property of nuclear hormone receptors. We report here that cell-specific repression by nuclear receptors correlates with levels of nuclear receptor corepressor (N-CoR) protein. N-CoR protein levels are regulated by mSiah2, a mammalian homolog of Drosophila Seven in absentia that targets N-CoR for proteasomal degradation. mSiah2 expression is cell-type specific and differentially regulates the repressive activities of nuclear receptors. These findings establish targeted proteolysis of transcriptional coregulators as a mechanism for cell-specific regulation of gene transcription.

Original languageEnglish (US)
Pages (from-to)1775-1780
Number of pages6
JournalGenes and Development
Issue number12
StatePublished - Jun 15 1998


  • Cell specificity
  • Nuclear receptor corepressor
  • Proteasomal regulation
  • Repression
  • RevErb
  • Thyroid hormone receptor

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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