Proteasomal regulation of pulmonary fibrosis

Curtis H. Weiss, G. R.Scott Budinger, Gökhan M. Mutlu, Manu Jain*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

It is estimated that, combined, 400,000 people are diagnosed with idiopathic pulmonary fibrosis (IPF) or acute lung injury/acute respiratory distress syndrome annually in the United States, and both diseases are associated with an unacceptably high mortality rate. Although these disorders are distinct clinical entities, they share pathogenic mechanisms that may provide overlapping therapeutic targets. One example is fibroblast activation, which occurs concomitant with acute lung injury as well as in the progressive fibrosis of IPF. Both clinical entities are characterized by elevations of the profibrotic cytokine, transforming growth factor (TGF)-β1. Protein degradation by the ubiquitin - proteasomal system modulates TGF-β1 expression and signaling. In this review, we highlight the effects of proteasomal inhibition in various animal models of tissue fibrosis and mechanisms by which it may regulate TGF-β1 expression and signaling. At present, there are no effective therapies for fibroproliferative acute respiratory distress syndrome or IPF, and proteasomal inhibition may provide a novel, attractive target in these devastating diseases.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalProceedings of the American Thoracic Society
Volume7
Issue number1
DOIs
StatePublished - Feb 15 2010

Keywords

  • Acute respiratory distress syndrome
  • Smad
  • Transforming growth factor-β1
  • Ubiquitination

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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