Protecting the future: balancing proteostasis for reproduction

Ambre J. Sala, Richard I. Morimoto*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

The proteostasis network (PN) regulates protein synthesis, folding, and degradation and is critical for the health and function of all cells. The PN has been extensively studied in the context of aging and age-related diseases, and loss of proteostasis is regarded as a major contributor to many age-associated disorders. In contrast to somatic tissues, an important feature of germ cells is their ability to maintain a healthy proteome across generations. Accumulating evidence has now revealed multiple layers of PN regulation that support germ cell function, determine reproductive capacity during aging, and prioritize reproduction at the expense of somatic health. Here, we review recent insights into these different modes of regulation and their implications for reproductive and somatic aging.

Original languageEnglish (US)
Pages (from-to)202-215
Number of pages14
JournalTrends in Cell Biology
Volume32
Issue number3
DOIs
StatePublished - Mar 2022

Funding

We thank Laura Bott, Jian Li, and Eugene Xu for critical reading of the manuscript. We apologize to authors whose work was not cited in this review due to space limitations. This work was supported by grants from the National Institutes of Health (National Institute on Aging RF1AG057296 and P01AG054407) and the Daniel F. and Ada L. Rice Foundation to R.I.M. The authors declare no interests.

Keywords

  • aging
  • oocyte
  • proteostasis
  • reproduction
  • stress response

ASJC Scopus subject areas

  • Cell Biology

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