Protecting the future: balancing proteostasis for reproduction

Ambre J. Sala, Richard I. Morimoto*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


The proteostasis network (PN) regulates protein synthesis, folding, and degradation and is critical for the health and function of all cells. The PN has been extensively studied in the context of aging and age-related diseases, and loss of proteostasis is regarded as a major contributor to many age-associated disorders. In contrast to somatic tissues, an important feature of germ cells is their ability to maintain a healthy proteome across generations. Accumulating evidence has now revealed multiple layers of PN regulation that support germ cell function, determine reproductive capacity during aging, and prioritize reproduction at the expense of somatic health. Here, we review recent insights into these different modes of regulation and their implications for reproductive and somatic aging.

Original languageEnglish (US)
Pages (from-to)202-215
Number of pages14
JournalTrends in Cell Biology
Issue number3
StatePublished - Mar 2022


  • aging
  • oocyte
  • proteostasis
  • reproduction
  • stress response

ASJC Scopus subject areas

  • Cell Biology


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