Protection by Dihydroergocryptine of Glutamate‐Induced Neurotoxicity

A. Favit*, M. A. Sortino, G. Aleppo, U. Scapagnini, P. L. Canonico

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Dihydroergocryptine is a hydrogenated ergot derivative with pharmacological actions mainly related to its dopaminomimetic activity. Here we report that dihydroergocryptine can protect cultured rat cerebellar granule cells against glutamate‐induced neurotoxicity, assessing cell viability with the fluorescein diacetate‐propidium iodide technique. Dihydroergocryptine antagonized both the neuronal death produced by acute exposure to a toxic glutamate concentration as well as the normal age‐dependent degeneration in culture. The effect of dihydroergocryptine might be mediated by a scavenger action as suggested by the fact that the compound in a concentration‐dependent manner reduced the formation of intracellular peroxides produced in cerebellar granule cells by exposure to 100 μM glutamate. This action is apparently not mediated entirely by interactions with the dopamine D 2 receptors. The neuroprotective action suggests that dihydroergocryptine might be a potential useful drug in the therapy and/or prophylaxis of acute and chronic neurodegenerative diseases related to excitotoxic damage. 1993 Nordic Pharmacological Society

Original languageEnglish (US)
Pages (from-to)224-228
Number of pages5
JournalPharmacology & Toxicology
Volume73
Issue number4
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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