Protective effect of flavonoids from Astragalus complanatus on radiation induced damages in mice

Lin Qi; Chun Yu Liu; Wen Qian Wu; Zhen Lun Gu; Ci Yi Guo

doi:10.1016/j.fitote.2010.11.015

Protective effect of flavonoids from Astragalus complanatus on radiation induced damages in mice

Lin Qi, Chun Yu Liu^*, Wen Qian Wu, Zhen Lun Gu, Ci Yi Guo

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

This study aimed to evaluate the radioprotective effect of flavonoids extracted from the seeds of Astragalus complanatus R.Br. (FAC) and their protective mechanism against radiation damage. FAC increased the survival rate of mice and made the damaged organ injured by ⁶⁰Co γ-irradiation recovered to normal appearance with the mechanism of enhancing immune function and blood-producing function in vivo. The molecule mechanism of FAC against radiation is involved in the reduction of DNA injury and mutation in vitro. Eleven monomers of the FAC were analyzed by HPLC. These results seem to support the use of FAC in relieving radiation damage.

Original language	English (US)
Pages (from-to)	383-392
Number of pages	10
Journal	Fitoterapia
Volume	82
Issue number	3
DOIs	https://doi.org/10.1016/j.fitote.2010.11.015
State	Published - Apr 2011

Keywords

DNA injury
Flavonoids from Astragalus complanatus
Hematopoietic function
Immune function
Radiation injury

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.fitote.2010.11.015

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title = "Protective effect of flavonoids from Astragalus complanatus on radiation induced damages in mice",

abstract = "This study aimed to evaluate the radioprotective effect of flavonoids extracted from the seeds of Astragalus complanatus R.Br. (FAC) and their protective mechanism against radiation damage. FAC increased the survival rate of mice and made the damaged organ injured by 60Co γ-irradiation recovered to normal appearance with the mechanism of enhancing immune function and blood-producing function in vivo. The molecule mechanism of FAC against radiation is involved in the reduction of DNA injury and mutation in vitro. Eleven monomers of the FAC were analyzed by HPLC. These results seem to support the use of FAC in relieving radiation damage.",

keywords = "DNA injury, Flavonoids from Astragalus complanatus, Hematopoietic function, Immune function, Radiation injury",

author = "Lin Qi and Liu, {Chun Yu} and Wu, {Wen Qian} and Gu, {Zhen Lun} and Guo, {Ci Yi}",

note = "Funding Information: This study was supported by the Natural Science Fund for Colleges and Universities in Jiangsu Province (No. 06KJB360105) in 2006.",

year = "2011",

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doi = "10.1016/j.fitote.2010.11.015",

language = "English (US)",

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pages = "383--392",

journal = "Fitoterapia",

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T1 - Protective effect of flavonoids from Astragalus complanatus on radiation induced damages in mice

AU - Qi, Lin

AU - Liu, Chun Yu

AU - Wu, Wen Qian

AU - Gu, Zhen Lun

AU - Guo, Ci Yi

N1 - Funding Information: This study was supported by the Natural Science Fund for Colleges and Universities in Jiangsu Province (No. 06KJB360105) in 2006.

PY - 2011/4

Y1 - 2011/4

N2 - This study aimed to evaluate the radioprotective effect of flavonoids extracted from the seeds of Astragalus complanatus R.Br. (FAC) and their protective mechanism against radiation damage. FAC increased the survival rate of mice and made the damaged organ injured by 60Co γ-irradiation recovered to normal appearance with the mechanism of enhancing immune function and blood-producing function in vivo. The molecule mechanism of FAC against radiation is involved in the reduction of DNA injury and mutation in vitro. Eleven monomers of the FAC were analyzed by HPLC. These results seem to support the use of FAC in relieving radiation damage.

AB - This study aimed to evaluate the radioprotective effect of flavonoids extracted from the seeds of Astragalus complanatus R.Br. (FAC) and their protective mechanism against radiation damage. FAC increased the survival rate of mice and made the damaged organ injured by 60Co γ-irradiation recovered to normal appearance with the mechanism of enhancing immune function and blood-producing function in vivo. The molecule mechanism of FAC against radiation is involved in the reduction of DNA injury and mutation in vitro. Eleven monomers of the FAC were analyzed by HPLC. These results seem to support the use of FAC in relieving radiation damage.

KW - DNA injury

KW - Flavonoids from Astragalus complanatus

KW - Hematopoietic function

KW - Immune function

KW - Radiation injury

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Protective effect of flavonoids from Astragalus complanatus on radiation induced damages in mice

Abstract

Keywords

ASJC Scopus subject areas

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