Protective effect of flavonoids from Astragalus complanatus on radiation induced damages in mice

Lin Qi, Chun Yu Liu*, Wen Qian Wu, Zhen Lun Gu, Ci Yi Guo

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

This study aimed to evaluate the radioprotective effect of flavonoids extracted from the seeds of Astragalus complanatus R.Br. (FAC) and their protective mechanism against radiation damage. FAC increased the survival rate of mice and made the damaged organ injured by 60Co γ-irradiation recovered to normal appearance with the mechanism of enhancing immune function and blood-producing function in vivo. The molecule mechanism of FAC against radiation is involved in the reduction of DNA injury and mutation in vitro. Eleven monomers of the FAC were analyzed by HPLC. These results seem to support the use of FAC in relieving radiation damage.

Original languageEnglish (US)
Pages (from-to)383-392
Number of pages10
JournalFitoterapia
Volume82
Issue number3
DOIs
StatePublished - Apr 1 2011

Keywords

  • DNA injury
  • Flavonoids from Astragalus complanatus
  • Hematopoietic function
  • Immune function
  • Radiation injury

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint Dive into the research topics of 'Protective effect of flavonoids from Astragalus complanatus on radiation induced damages in mice'. Together they form a unique fingerprint.

  • Cite this