Protective effect of total glucosides of paeony on joint damage in adjuvant arthritis rats

B. Wang*, Y. Y. Yao, A. W. Zhou, Zhi-Dong Ge, M. Z. Chen, S. Y. Xu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The protective effect of total glucosides of paeony (TGP) on joint damage was studied by measuring the volume of non-injected hind paw, plasma malondialdehyde (MDA) content, superoxide dismutase (SOD) activity of red blood cells, glutathione peroxidase (GSHPx) activity in blood, nitrite and tumor necrosis factor (TNF) released from peritoneal macrophages (PM(Φ)) of adjuvant arthritis (AA) rats in different periods. The results showed that treatments of AA rats with TGP (50 mg · kg-1 · d-1, ig x 14-28 d) could not only markedly inhibit paw swelling in AA rats, but also down-regulate their elevated MDA, nitrite and TNF contents as well as up-regulate their diminished SOD and GSHPx activity to normal levels. Correlative analysis suggested that suppression of arthritis of TGP could be associated with its reduction of elevated lipid peroxidation and restoration of anti-oxidative enzymes and the secretion of PM(Φ).

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalChinese Journal of Pharmacology and Toxicology
Volume10
Issue number3
StatePublished - Jan 1 1996

Keywords

  • arthritis, adjuvant
  • glutathione peroxidase
  • lipid peroxidation
  • nitric oxide
  • saponins, Radix paeoniae Alba
  • superoxide dismutase
  • tumor necrosis factor

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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