Protective Efficacy of coenzyme Q 10 against DDVP-Induced cognitive impairments and neurodegeneration in rats

B. K. Binukumar, Nidhi Gupta, Aditya Sunkaria, Ramesh Kandimalla, W. Y. Wani, D. R. Sharma, Amanjit Bal, Kiran Dip Gill*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The present study was carried out to elucidate the effects of coenzyme Q 10 (CoQ 10) against cognitive impairments induced by dichlorvos (DDVP). We have previously shown organophosphate, DDVP-induced impairments in neurobehavioral indices viz. rota rod, passive avoidance, and water maze tests. In addition to this, we have also reported that chronic DDVP exposure leads to decreased mitochondrial electron transfer activities of cytochrome oxidase along with altered mitochondrial complexes I-III activity. Administration of CoQ 10 (4.5 mg/kg, i.p. for 12 weeks prior to DDVP administration daily) to DDVP-treated rats improved cognitive performance in passive avoidance task and Morris water maze test. Furthermore, CoQ 10 treatment also reduced oxidative stress (as evident by reduced malondialdehyde, decreased ROS and increased Mn-SOD activity) in DDVP-treated rats' hippocampus region, along with enhanced activity of complexes I-III and complex IV. Electron microscope studies of rat hippocampus mitochondria revealed that CoQ 10 administration leads to near normal physiology of mitochondria with well-defined cristae compared with DDVP-treated animals where enlarged mitochondria with distorted cristae are observed. CoQ 10 administration also attenuated neuronal damage in hippocampus as evident from histopathological studies. These results demonstrate the beneficial effects of CoQ 10 against organophosphateinduced cognitive impairments and hippocampal neuronal degeneration.

Original languageEnglish (US)
Pages (from-to)345-357
Number of pages13
JournalNeurotoxicity Research
Volume21
Issue number4
DOIs
StatePublished - May 2012

Keywords

  • Acetylcholinesterase
  • DDVP
  • Memory
  • Organophosphate
  • Oxidative damage

ASJC Scopus subject areas

  • General Neuroscience
  • Toxicology

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