Protein C antigen deficiency and warfarin necrosis

V. L. Rose, Hau C. Kwaan, K. Williamson, D. Hoppensteadt, J. Walenga, J. Fareed

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50 Scopus citations


Recent reports have suggested a correlation between congenital protein C deficiency and tissue necrosis complicating oral anticoagulants (warfarin necrosis). The authors studied blood samples of 13 patients, obtained two weeks to more than six months after warfarin necrosis. Protein C antigens levels were assayed by an enzyme-linked immunosorbent assay method (Diagnostica Stago, France). Factors II, VII, IX, and X were assayed by functional methods, and IX and X additionally by immunologic methods. The results show that 11 of 13 patients with a history of tissue necrosis had low protein C levels, ranging from 23 to 69%, with the normal range being 70-140%. These results confirm that low protein C antigen levels are implicated in the pathogenesis of warfarin necrosis.

Original languageEnglish (US)
Pages (from-to)653-655
Number of pages3
JournalAmerican Journal of Clinical Pathology
Issue number5
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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