Protein C deficiency in splanchnic venous thrombosis

David Green*, Daniel R Ganger, Andres T. Blei

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Deficiencies of protein C activity and antigen were observed in eight consecutive patients with splanchnic venous thrombosis. There was a significant reduction in the ratio of protein C to factor X. Six of the eight patients had a decrease in antithrombin III, but free protein S antigen was within normal limits in all but two subjects. It is proposed that a thrombogenic stimulus such as stasis, altered hormonal milieu, or failure of hepatic clearance of activated coagulants results in consumption of protein C and antithrombin III, predisposing to splanchnic venous occlusion. This further impairs hepatic function, prevents restitution of protein C and antithrombin levels, and promotes continuing venous thrombosis. Thus, a vicious cycle of thrombosis and hepatic damage is perpetuated.

Original languageEnglish (US)
Pages (from-to)1171-1174
Number of pages4
JournalThe American Journal of Medicine
Volume82
Issue number6
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Nursing(all)

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