Protein F1/GAP-43 and PKC gene expression patterns in hippocampus are altered 1-2 h after LTP

Peter J. Meberg, Eric G. Valcourt, Aryeh Routtenberg*

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Three days after long-term potentiation (LTP) there is a decrease in the gene expression of protein F1 (GAP-43) and γ-PKC in CA3 pyramidal cells that is correlated with the magnitude of LTP. We predicted these decreases would be preceded by an increment in gene expression. At 1 h, but not at 2 h after LTP, F1/GAP-43 and γ-PKC mRNA hybridization were increased, but increases were also observed after control stimulation. At both 1 and 2 h after LTP, changes in F1/GAP-43 hybridization were positively correlated with γ-PKC hybridization and negatively correlated with LTP magnitude. These data indicate that correlated alterations in F1/GAP-43 gene expression and synaptic efficacy can occur as early as 1 h after LTP and persist for days.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalMolecular Brain Research
Volume34
Issue number2
DOIs
StatePublished - Dec 28 1995

Keywords

  • CA3
  • GAP-43
  • Gene expression
  • Hippocampus
  • Long-term potentiation
  • Protein F1
  • Protein kinase C

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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