TY - JOUR
T1 - Protein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal, histiocytic, and melanocytic lesions
T2 - comparison with cellular neurothekeoma
AU - Wang, Grace Y.
AU - Nazarian, Rosalynn M.
AU - Zhao, Lili
AU - Hristov, Alexandra C.
AU - Patel, Rajiv M.
AU - Fullen, Douglas R.
AU - Chan, May P.
N1 - Publisher Copyright:
© 2016 Royal College of Pathologists of Australasia
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Cellular neurothekeoma (CNTK) frequently enters the differential diagnosis of a benign dermal cellular proliferation. Diagnosis often relies on immunohistochemistry including the use of protein gene product 9.5 (PGP9.5). A previous study demonstrated PGP9.5 expression across a wide variety of soft tissue neoplasms. We explored the utility of this antibody in distinguishing CNTK from other benign dermal-based lesions. A cohort of CNTK (n = 7) and benign cutaneous lesions of neural (n = 28), fibrohistiocytic (n = 23), fibroblastic (n = 25), histiocytic (n = 18), myofibroblastic (n = 7), smooth muscle (n = 14), and melanocytic (n = 12) differentiations were immunostained with PGP9.5. Staining was graded by H-score and compared with CNTK. A significantly higher H-score was found in CNTK compared with the fibrohistiocytic (p = 0.0001), histiocytic (p = 0.0016), myofibroblastic (p = 0.0003), smooth muscle (p < 0.0001), and melanocytic (p = 0.0004) groups, with the exceptions of plexiform fibrohistiocytic tumour, xanthoma, and xanthogranuloma. No significant difference was found when comparing CNTK with fibroblastic and neural lesions, with the exceptions of neurofibroma and perineurioma. In conclusion, PGP9.5 is helpful in distinguishing CNTK from most benign cutaneous fibrohistiocytic, histiocytic, myofibroblastic, smooth muscle, and melanocytic lesions. In addition to CNTK and neural lesions, PGP9.5 is also expressed in benign fibroblastic lesions, and therefore distinction of these lesions should not be based on PGP9.5 positivity.
AB - Cellular neurothekeoma (CNTK) frequently enters the differential diagnosis of a benign dermal cellular proliferation. Diagnosis often relies on immunohistochemistry including the use of protein gene product 9.5 (PGP9.5). A previous study demonstrated PGP9.5 expression across a wide variety of soft tissue neoplasms. We explored the utility of this antibody in distinguishing CNTK from other benign dermal-based lesions. A cohort of CNTK (n = 7) and benign cutaneous lesions of neural (n = 28), fibrohistiocytic (n = 23), fibroblastic (n = 25), histiocytic (n = 18), myofibroblastic (n = 7), smooth muscle (n = 14), and melanocytic (n = 12) differentiations were immunostained with PGP9.5. Staining was graded by H-score and compared with CNTK. A significantly higher H-score was found in CNTK compared with the fibrohistiocytic (p = 0.0001), histiocytic (p = 0.0016), myofibroblastic (p = 0.0003), smooth muscle (p < 0.0001), and melanocytic (p = 0.0004) groups, with the exceptions of plexiform fibrohistiocytic tumour, xanthoma, and xanthogranuloma. No significant difference was found when comparing CNTK with fibroblastic and neural lesions, with the exceptions of neurofibroma and perineurioma. In conclusion, PGP9.5 is helpful in distinguishing CNTK from most benign cutaneous fibrohistiocytic, histiocytic, myofibroblastic, smooth muscle, and melanocytic lesions. In addition to CNTK and neural lesions, PGP9.5 is also expressed in benign fibroblastic lesions, and therefore distinction of these lesions should not be based on PGP9.5 positivity.
KW - Cellular neurothekeoma
KW - immunohistochemistry
KW - PGP9.5
UR - http://www.scopus.com/inward/record.url?scp=85006355993&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006355993&partnerID=8YFLogxK
U2 - 10.1016/j.pathol.2016.09.061
DO - 10.1016/j.pathol.2016.09.061
M3 - Article
C2 - 27914685
AN - SCOPUS:85006355993
SN - 0031-3025
VL - 49
SP - 44
EP - 49
JO - Pathology
JF - Pathology
IS - 1
ER -