TY - CHAP
T1 - Protein homeostasis in models of aging and age-related conformational disease
AU - Kikis, Elise A.
AU - Gidalevitz, Tali
AU - Morimoto, Richard I.
PY - 2010
Y1 - 2010
N2 - The stability of the proteome is crucial to the health of the cell, and contributes significantly to the lifespan of the organism. Aging and many age-related diseases have in common the expression of misfolded and damaged proteins. The chronic expression of damaged proteins during disease can have devastating consequences on protein homeostasis (proteostasis), resulting in disruption of numerous biological processes. This chapter discusses our current understanding of the various contributors to protein misfolding, and the mechanisms by which misfolding, and accompanied aggregation/toxicity, is accelerated by stress and aging. Invertebrate models have been instrumental in studying the processes related to aggregation and toxicity of disease-associated proteins and how dysregulation of proteostasis leads to neurodegenerative diseases of aging.
AB - The stability of the proteome is crucial to the health of the cell, and contributes significantly to the lifespan of the organism. Aging and many age-related diseases have in common the expression of misfolded and damaged proteins. The chronic expression of damaged proteins during disease can have devastating consequences on protein homeostasis (proteostasis), resulting in disruption of numerous biological processes. This chapter discusses our current understanding of the various contributors to protein misfolding, and the mechanisms by which misfolding, and accompanied aggregation/toxicity, is accelerated by stress and aging. Invertebrate models have been instrumental in studying the processes related to aggregation and toxicity of disease-associated proteins and how dysregulation of proteostasis leads to neurodegenerative diseases of aging.
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U2 - 10.1007/978-1-4419-7002-2_11
DO - 10.1007/978-1-4419-7002-2_11
M3 - Chapter
C2 - 20886762
AN - SCOPUS:78049383942
SN - 9781441970015
T3 - Advances in Experimental Medicine and Biology
SP - 138
EP - 159
BT - Protein Metabolism and Homeostasis in Aging
A2 - Tavernarakis, Nektarios
ER -