Protein homeostasis in models of aging and age-related conformational disease

Elise A. Kikis, Tali Gidalevitz, Richard I. Morimoto*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

144 Scopus citations


The stability of the proteome is crucial to the health of the cell, and contributes significantly to the lifespan of the organism. Aging and many age-related diseases have in common the expression of misfolded and damaged proteins. The chronic expression of damaged proteins during disease can have devastating consequences on protein homeostasis (proteostasis), resulting in disruption of numerous biological processes. This chapter discusses our current understanding of the various contributors to protein misfolding, and the mechanisms by which misfolding, and accompanied aggregation/toxicity, is accelerated by stress and aging. Invertebrate models have been instrumental in studying the processes related to aggregation and toxicity of disease-associated proteins and how dysregulation of proteostasis leads to neurodegenerative diseases of aging.

Original languageEnglish (US)
Title of host publicationProtein Metabolism and Homeostasis in Aging
EditorsNektarios Tavernarakis
Number of pages22
StatePublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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