Protein kinase C signalling in leukemia

Amanda J. Redig, Leonidas C. Platanias*

*Corresponding author for this work

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

The protein kinase C (PKC) family of proteins includes several kinases that share structural homology, but at the same time exhibit substantial functional diversity. There is a significant amount of evidence establishing distinct patterns of expression and function for different PKC isoforms and groups in different leukemias. Although most members of this family promote leukemic cell survival and growth, others exhibit opposing effects and participate in the generation of antileukemic responses. This review summarizes work in this field on the relevance of distinct members of the PKC family in the pathophysiology of myeloid and lymphoid leukemias. The clinical-therapeutic potential of such ongoing work for the treatment of future development of novel approaches for the treatment of different types of leukemias is discussed.

Original languageEnglish (US)
Pages (from-to)1255-1262
Number of pages8
JournalLeukemia and Lymphoma
Volume49
Issue number7
DOIs
StatePublished - Jul 1 2008

Keywords

  • Lymphoid leukemia
  • Myeloid leukemia and dysplasias
  • Neoplasia
  • Signal transduction

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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