Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine

Hari Shanker Sharma*, Seaab Sahib, Z. Ryan Tian, Dafin F. Muresanu, Ala Nozari, Rudy J. Castellani, José Vicente Lafuente, Lars Wiklund, Aruna Sharma

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations


Traumatic brain injury (TBI) causes physical injury to the cell membranes of neurons, glial and axons causing the release of several neurochemicals including glutamate and cytokines altering cell-signaling pathways. Upregulation of mitogen associated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) occurs that is largely responsible for cell death. The pharmacological blockade of these pathways results in cell survival. In this review role of several protein kinase inhibitors on TBI induced oxidative stress, blood-brain barrier breakdown, brain edema formation, and resulting brain pathology is discussed in the light of current literature.

Original languageEnglish (US)
Title of host publicationNeuropharmacology of Neuroprotection
EditorsHari Shanker Sharma, Aruna Sharma
PublisherElsevier B.V.
Number of pages51
ISBN (Print)9780128208137
StatePublished - Jan 2020

Publication series

NameProgress in Brain Research
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855


  • Blood-brain barrier
  • Brain edema
  • Brain pathology
  • Methylene blue
  • Nanowired delivery
  • Oxidative stress
  • Protein kinase inhibitors
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)


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