@inbook{328a9a50d67e4908bc0dae3a94811926,
title = "Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine",
abstract = "Traumatic brain injury (TBI) causes physical injury to the cell membranes of neurons, glial and axons causing the release of several neurochemicals including glutamate and cytokines altering cell-signaling pathways. Upregulation of mitogen associated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) occurs that is largely responsible for cell death. The pharmacological blockade of these pathways results in cell survival. In this review role of several protein kinase inhibitors on TBI induced oxidative stress, blood-brain barrier breakdown, brain edema formation, and resulting brain pathology is discussed in the light of current literature.",
keywords = "Blood-brain barrier, Brain edema, Brain pathology, Methylene blue, Nanowired delivery, Oxidative stress, Protein kinase inhibitors, Traumatic brain injury",
author = "Sharma, {Hari Shanker} and Seaab Sahib and Tian, {Z. Ryan} and Muresanu, {Dafin F.} and Ala Nozari and Castellani, {Rudy J.} and Lafuente, {Jos{\'e} Vicente} and Lars Wiklund and Aruna Sharma",
note = "Funding Information: This investigation is supported by grants from the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065; Grants from the Alzheimer's Association (IIRG-09- 132087), the National Institutes of Health (R01 AG028679) and the Dr. Robert M. Kohrman Memorial Fund (RJC); Swedish Medical Research Council (Nr 2710-HSS), G{\"o}ran Gustafsson Foundation, Stockholm, Sweden (HSS), Astra Zeneca, M{\"o}lndal, Sweden (HSS/AS), The University Grants Commission, New Delhi, India (HSS/AS), Ministry of Science & Technology, Govt. of India (HSS/AS), Indian Medical Research Council, New Delhi, India (HSS/AS) and India-EU Co-operation Program (RP/AS/HSS) and IT-901/16 (JVL), Government of Basque Country and PPG 17/51 (JVL) University of the Basque Country, Spain, & Society for Neuroprotection and Neuroplasticity (SSNN), Romania. Dr. Seaab Sahib is supported by Research Fellowship at University of Arkansas Fayetteville AR by Department of Community Health; Middle Technical University; Wassit; Iraq, and The Higher Committee for Education Development in Iraq; Baghdad; Iraq. Technical and human support provided by Dr. Ricardo Andrade from SGIker (UPV/EHU) is gratefully acknowledged. We thank Suraj Sharma, Blekinge Inst. Technology, Karlskrona, Sweden for computer and graphic support. The U.S. Government is authorized to reproduce and distribute reprints for Government purpose notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Air Force Office of Scientific Research or the U.S. Government. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2020",
month = jan,
doi = "10.1016/bs.pbr.2020.09.009",
language = "English (US)",
isbn = "9780128208137",
series = "Progress in Brain Research",
publisher = "Elsevier B.V.",
pages = "233--283",
editor = "Sharma, {Hari Shanker} and Aruna Sharma",
booktitle = "Neuropharmacology of Neuroprotection",
}