Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine

Hari Shanker Sharma; Seaab Sahib; Z. Ryan Tian; Dafin F. Muresanu; Ala Nozari; Rudy J. Castellani; José Vicente Lafuente; Lars Wiklund; Aruna Sharma

doi:10.1016/bs.pbr.2020.09.009

Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine

Hari Shanker Sharma^*, Seaab Sahib, Z. Ryan Tian, Dafin F. Muresanu, Ala Nozari, Rudy J. Castellani, José Vicente Lafuente, Lars Wiklund, Aruna Sharma

^*Corresponding author for this work

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

14 Scopus citations

Abstract

Traumatic brain injury (TBI) causes physical injury to the cell membranes of neurons, glial and axons causing the release of several neurochemicals including glutamate and cytokines altering cell-signaling pathways. Upregulation of mitogen associated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) occurs that is largely responsible for cell death. The pharmacological blockade of these pathways results in cell survival. In this review role of several protein kinase inhibitors on TBI induced oxidative stress, blood-brain barrier breakdown, brain edema formation, and resulting brain pathology is discussed in the light of current literature.

Original language	English (US)
Title of host publication	Neuropharmacology of Neuroprotection
Editors	Hari Shanker Sharma, Aruna Sharma
Publisher	Elsevier B.V.
Pages	233-283
Number of pages	51
ISBN (Print)	9780128208137
DOIs	https://doi.org/10.1016/bs.pbr.2020.09.009
State	Published - Jan 2020

Publication series

Name	Progress in Brain Research
Volume	258
ISSN (Print)	0079-6123
ISSN (Electronic)	1875-7855

Funding

This investigation is supported by grants from the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065; Grants from the Alzheimer's Association (IIRG-09- 132087), the National Institutes of Health (R01 AG028679) and the Dr. Robert M. Kohrman Memorial Fund (RJC); Swedish Medical Research Council (Nr 2710-HSS), Göran Gustafsson Foundation, Stockholm, Sweden (HSS), Astra Zeneca, Mölndal, Sweden (HSS/AS), The University Grants Commission, New Delhi, India (HSS/AS), Ministry of Science & Technology, Govt. of India (HSS/AS), Indian Medical Research Council, New Delhi, India (HSS/AS) and India-EU Co-operation Program (RP/AS/HSS) and IT-901/16 (JVL), Government of Basque Country and PPG 17/51 (JVL) University of the Basque Country, Spain, & Society for Neuroprotection and Neuroplasticity (SSNN), Romania. Dr. Seaab Sahib is supported by Research Fellowship at University of Arkansas Fayetteville AR by Department of Community Health; Middle Technical University; Wassit; Iraq, and The Higher Committee for Education Development in Iraq; Baghdad; Iraq. Technical and human support provided by Dr. Ricardo Andrade from SGIker (UPV/EHU) is gratefully acknowledged. We thank Suraj Sharma, Blekinge Inst. Technology, Karlskrona, Sweden for computer and graphic support. The U.S. Government is authorized to reproduce and distribute reprints for Government purpose notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Air Force Office of Scientific Research or the U.S. Government.

Keywords

Blood-brain barrier
Brain edema
Brain pathology
Methylene blue
Nanowired delivery
Oxidative stress
Protein kinase inhibitors
Traumatic brain injury

ASJC Scopus subject areas

General Neuroscience

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10.1016/bs.pbr.2020.09.009

Cite this

Sharma, H. S., Sahib, S., Tian, Z. R., Muresanu, D. F., Nozari, A., Castellani, R. J., Lafuente, J. V., Wiklund, L., & Sharma, A. (2020). Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine. In H. S. Sharma, & A. Sharma (Eds.), Neuropharmacology of Neuroprotection (pp. 233-283). (Progress in Brain Research; Vol. 258). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2020.09.009

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title = "Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine",

abstract = "Traumatic brain injury (TBI) causes physical injury to the cell membranes of neurons, glial and axons causing the release of several neurochemicals including glutamate and cytokines altering cell-signaling pathways. Upregulation of mitogen associated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) occurs that is largely responsible for cell death. The pharmacological blockade of these pathways results in cell survival. In this review role of several protein kinase inhibitors on TBI induced oxidative stress, blood-brain barrier breakdown, brain edema formation, and resulting brain pathology is discussed in the light of current literature.",

keywords = "Blood-brain barrier, Brain edema, Brain pathology, Methylene blue, Nanowired delivery, Oxidative stress, Protein kinase inhibitors, Traumatic brain injury",

author = "Sharma, {Hari Shanker} and Seaab Sahib and Tian, {Z. Ryan} and Muresanu, {Dafin F.} and Ala Nozari and Castellani, {Rudy J.} and Lafuente, {Jos{\'e} Vicente} and Lars Wiklund and Aruna Sharma",

note = "Funding Information: This investigation is supported by grants from the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065; Grants from the Alzheimer's Association (IIRG-09- 132087), the National Institutes of Health (R01 AG028679) and the Dr. Robert M. Kohrman Memorial Fund (RJC); Swedish Medical Research Council (Nr 2710-HSS), G{\"o}ran Gustafsson Foundation, Stockholm, Sweden (HSS), Astra Zeneca, M{\"o}lndal, Sweden (HSS/AS), The University Grants Commission, New Delhi, India (HSS/AS), Ministry of Science & Technology, Govt. of India (HSS/AS), Indian Medical Research Council, New Delhi, India (HSS/AS) and India-EU Co-operation Program (RP/AS/HSS) and IT-901/16 (JVL), Government of Basque Country and PPG 17/51 (JVL) University of the Basque Country, Spain, & Society for Neuroprotection and Neuroplasticity (SSNN), Romania. Dr. Seaab Sahib is supported by Research Fellowship at University of Arkansas Fayetteville AR by Department of Community Health; Middle Technical University; Wassit; Iraq, and The Higher Committee for Education Development in Iraq; Baghdad; Iraq. Technical and human support provided by Dr. Ricardo Andrade from SGIker (UPV/EHU) is gratefully acknowledged. We thank Suraj Sharma, Blekinge Inst. Technology, Karlskrona, Sweden for computer and graphic support. The U.S. Government is authorized to reproduce and distribute reprints for Government purpose notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Air Force Office of Scientific Research or the U.S. Government. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = jan,

doi = "10.1016/bs.pbr.2020.09.009",

language = "English (US)",

isbn = "9780128208137",

series = "Progress in Brain Research",

publisher = "Elsevier B.V.",

pages = "233--283",

editor = "Sharma, {Hari Shanker} and Aruna Sharma",

booktitle = "Neuropharmacology of Neuroprotection",

}

Sharma, HS, Sahib, S, Tian, ZR, Muresanu, DF, Nozari, A, Castellani, RJ, Lafuente, JV, Wiklund, L & Sharma, A 2020, Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine. in HS Sharma & A Sharma (eds), Neuropharmacology of Neuroprotection. Progress in Brain Research, vol. 258, Elsevier B.V., pp. 233-283. https://doi.org/10.1016/bs.pbr.2020.09.009

Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine. / Sharma, Hari Shanker; Sahib, Seaab; Tian, Z. Ryan et al.
Neuropharmacology of Neuroprotection. ed. / Hari Shanker Sharma; Aruna Sharma. Elsevier B.V., 2020. p. 233-283 (Progress in Brain Research; Vol. 258).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - Protein kinase inhibitors in traumatic brain injury and repair

T2 - New roles of nanomedicine

AU - Sharma, Hari Shanker

AU - Sahib, Seaab

AU - Tian, Z. Ryan

AU - Muresanu, Dafin F.

AU - Nozari, Ala

AU - Castellani, Rudy J.

AU - Lafuente, José Vicente

AU - Wiklund, Lars

AU - Sharma, Aruna

N1 - Funding Information: This investigation is supported by grants from the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065; Grants from the Alzheimer's Association (IIRG-09- 132087), the National Institutes of Health (R01 AG028679) and the Dr. Robert M. Kohrman Memorial Fund (RJC); Swedish Medical Research Council (Nr 2710-HSS), Göran Gustafsson Foundation, Stockholm, Sweden (HSS), Astra Zeneca, Mölndal, Sweden (HSS/AS), The University Grants Commission, New Delhi, India (HSS/AS), Ministry of Science & Technology, Govt. of India (HSS/AS), Indian Medical Research Council, New Delhi, India (HSS/AS) and India-EU Co-operation Program (RP/AS/HSS) and IT-901/16 (JVL), Government of Basque Country and PPG 17/51 (JVL) University of the Basque Country, Spain, & Society for Neuroprotection and Neuroplasticity (SSNN), Romania. Dr. Seaab Sahib is supported by Research Fellowship at University of Arkansas Fayetteville AR by Department of Community Health; Middle Technical University; Wassit; Iraq, and The Higher Committee for Education Development in Iraq; Baghdad; Iraq. Technical and human support provided by Dr. Ricardo Andrade from SGIker (UPV/EHU) is gratefully acknowledged. We thank Suraj Sharma, Blekinge Inst. Technology, Karlskrona, Sweden for computer and graphic support. The U.S. Government is authorized to reproduce and distribute reprints for Government purpose notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Air Force Office of Scientific Research or the U.S. Government. Publisher Copyright: © 2020 Elsevier B.V.

PY - 2020/1

Y1 - 2020/1

N2 - Traumatic brain injury (TBI) causes physical injury to the cell membranes of neurons, glial and axons causing the release of several neurochemicals including glutamate and cytokines altering cell-signaling pathways. Upregulation of mitogen associated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) occurs that is largely responsible for cell death. The pharmacological blockade of these pathways results in cell survival. In this review role of several protein kinase inhibitors on TBI induced oxidative stress, blood-brain barrier breakdown, brain edema formation, and resulting brain pathology is discussed in the light of current literature.

AB - Traumatic brain injury (TBI) causes physical injury to the cell membranes of neurons, glial and axons causing the release of several neurochemicals including glutamate and cytokines altering cell-signaling pathways. Upregulation of mitogen associated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) occurs that is largely responsible for cell death. The pharmacological blockade of these pathways results in cell survival. In this review role of several protein kinase inhibitors on TBI induced oxidative stress, blood-brain barrier breakdown, brain edema formation, and resulting brain pathology is discussed in the light of current literature.

KW - Blood-brain barrier

KW - Brain edema

KW - Brain pathology

KW - Methylene blue

KW - Nanowired delivery

KW - Oxidative stress

KW - Protein kinase inhibitors

KW - Traumatic brain injury

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SN - 9780128208137

T3 - Progress in Brain Research

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BT - Neuropharmacology of Neuroprotection

A2 - Sharma, Hari Shanker

A2 - Sharma, Aruna

PB - Elsevier B.V.

ER -

Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine

Abstract

Publication series

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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