Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies

Hong Jiang, Xiaoyu Zhang, Xiao Chen, Pornpun Aramsangtienchai, Zhen Tong, Hening Lin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

159 Scopus citations

Abstract

Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic cells and regulates numerous biological pathways, such as membrane trafficking, protein secretion, signal transduction, and apoptosis. We provide a comprehensive review of protein lipidation, including descriptions of proteins known to be modified and the functions of the modifications, the enzymes that control them, and the tools and technologies developed to study them. We also highlight key questions about protein lipidation that remain to be answered, the challenges associated with answering such questions, and possible solutions to overcome these challenges.

Original languageEnglish (US)
Pages (from-to)919-988
Number of pages70
JournalChemical Reviews
Volume118
Issue number3
DOIs
StatePublished - Feb 14 2018
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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