Protein Quality Control in Neurodegenerative Diseases

Richard I Morimoto (Editor), Yves Christen (Editor)

Research output: Book/ReportBook

Abstract

The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
Original languageEnglish (US)
PublisherSpringer-Verlag Berlin Heidelberg
Number of pages136
Edition1
ISBN (Electronic)978-3-642-27928-7
ISBN (Print)978-3-642-27927-0
StatePublished - 2013

Publication series

Name978-3-642-27928-7
ISSN (Print)0945-6066

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