Protein synthesis inhibitors, gene superinduction and memory: Too little or too much protein?

Jelena Radulovic*, Natalie C. Tronson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

To date, the effects of protein synthesis inhibitors (PSI) in learning and memory processes have been attributed to translational arrest and consequent inhibition of de novo protein synthesis. Here we argue that amnesia produced by PSI can be the direct result of their abnormal induction of mRNA-a process termed gene superinduction. This action exerted by PSI involves an abundant and prolonged accumulation of mRNA transcripts of genes that are normally transiently induced. We summarize experimental evidence for the multiple mechanisms and signaling pathways mediating gene superinduction and consider its relevance for PSI-induced amnesia. This mechanistic alternative to protein synthesis inhibition is compared to models of electroconvulsive seizures and fragile × syndrome associated with enhanced mRNA/protein levels and cognitive deficits.

Original languageEnglish (US)
Pages (from-to)212-218
Number of pages7
JournalNeurobiology of Learning and Memory
Volume89
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Anisomycin
  • Consolidation
  • Cycloheximide
  • Extinction
  • Gene superinduction
  • Memory
  • Protein synthesis inhibitor
  • Reconsolidation

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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