Protein/carbon nanotubes interaction: The effect of carboxylic groups on conformational and conductance changes

C. Raman Suri; I. Putu Mahendra Wijaya; Sonu Gandhi; Tey Ju Nie; Nishima Wangoo; Isabel Rodriguez; G. Shekhawat; Subodh G. Mhaisalkar

doi:10.1063/1.3211328

Protein/carbon nanotubes interaction: The effect of carboxylic groups on conformational and conductance changes

C. Raman Suri, I. Putu Mahendra Wijaya, Sonu Gandhi, Tey Ju Nie, Nishima Wangoo, Isabel Rodriguez, G. Shekhawat, Subodh G. Mhaisalkar

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Detailed understanding of interaction between biomolecules and single-walled carbon nanotubes (SWCNTs) is important in the design and applications of biosensors that employ SWCNTs for transduction of the analytes response. Reciprocal interactions of SWCNT with bovine serum albumin are investigated here with pristine and carboxylated nanotubes. Carboxylic functionalization was found to inflict a deeper change on protein conformation, than their pristine counterparts, accompanied with a change in nanotube conductance. This observation has significant implications for biosensors in highlighting the need to take into account the surface functionalization state of the active materials.

Original language	English (US)
Article number	073704
Journal	Applied Physics Letters
Volume	95
Issue number	7
DOIs	https://doi.org/10.1063/1.3211328
State	Published - 2009

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

Access to Document

10.1063/1.3211328

Cite this

@article{8fc6a0c075d0464abe7a23e9ce70fbce,

title = "Protein/carbon nanotubes interaction: The effect of carboxylic groups on conformational and conductance changes",

abstract = "Detailed understanding of interaction between biomolecules and single-walled carbon nanotubes (SWCNTs) is important in the design and applications of biosensors that employ SWCNTs for transduction of the analytes response. Reciprocal interactions of SWCNT with bovine serum albumin are investigated here with pristine and carboxylated nanotubes. Carboxylic functionalization was found to inflict a deeper change on protein conformation, than their pristine counterparts, accompanied with a change in nanotube conductance. This observation has significant implications for biosensors in highlighting the need to take into account the surface functionalization state of the active materials.",

author = "Suri, {C. Raman} and {Mahendra Wijaya}, {I. Putu} and Sonu Gandhi and {Ju Nie}, Tey and Nishima Wangoo and Isabel Rodriguez and G. Shekhawat and Mhaisalkar, {Subodh G.}",

note = "Funding Information: I.P.M.W. and S.G. contributed equally to this work. This works was supported by Nanyang Technololgical University School of Materials Science and Engineering and Institute of Materials Research and Engineering. ",

year = "2009",

doi = "10.1063/1.3211328",

language = "English (US)",

volume = "95",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics Publising LLC",

number = "7",

}

TY - JOUR

T1 - Protein/carbon nanotubes interaction

T2 - The effect of carboxylic groups on conformational and conductance changes

AU - Suri, C. Raman

AU - Mahendra Wijaya, I. Putu

AU - Gandhi, Sonu

AU - Ju Nie, Tey

AU - Wangoo, Nishima

AU - Rodriguez, Isabel

AU - Shekhawat, G.

AU - Mhaisalkar, Subodh G.

N1 - Funding Information: I.P.M.W. and S.G. contributed equally to this work. This works was supported by Nanyang Technololgical University School of Materials Science and Engineering and Institute of Materials Research and Engineering.

PY - 2009

Y1 - 2009

N2 - Detailed understanding of interaction between biomolecules and single-walled carbon nanotubes (SWCNTs) is important in the design and applications of biosensors that employ SWCNTs for transduction of the analytes response. Reciprocal interactions of SWCNT with bovine serum albumin are investigated here with pristine and carboxylated nanotubes. Carboxylic functionalization was found to inflict a deeper change on protein conformation, than their pristine counterparts, accompanied with a change in nanotube conductance. This observation has significant implications for biosensors in highlighting the need to take into account the surface functionalization state of the active materials.

AB - Detailed understanding of interaction between biomolecules and single-walled carbon nanotubes (SWCNTs) is important in the design and applications of biosensors that employ SWCNTs for transduction of the analytes response. Reciprocal interactions of SWCNT with bovine serum albumin are investigated here with pristine and carboxylated nanotubes. Carboxylic functionalization was found to inflict a deeper change on protein conformation, than their pristine counterparts, accompanied with a change in nanotube conductance. This observation has significant implications for biosensors in highlighting the need to take into account the surface functionalization state of the active materials.

UR - http://www.scopus.com/inward/record.url?scp=69249171103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69249171103&partnerID=8YFLogxK

U2 - 10.1063/1.3211328

DO - 10.1063/1.3211328

M3 - Article

AN - SCOPUS:69249171103

SN - 0003-6951

VL - 95

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 7

M1 - 073704

ER -

Protein/carbon nanotubes interaction: The effect of carboxylic groups on conformational and conductance changes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this