Proteome remodeling and organelle clearance in mammalian terminal erythropoiesis

Kehan Ren, Ermin Li, Peng Ji*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Purpose of review The differentiation from colony forming unit-erythroid (CFU-E) cells to mature enucleated red blood cells is named terminal erythropoiesis in mammals. Apart from enucleation, several unique features during these developmental stages include proteome remodeling and organelle clearance that are important to achieve hemoglobin enrichment. Here, we review the recent advances in the understanding of novel regulatory mechanisms in these processes, focusing on the master regulators that link these major events during terminal erythropoiesis. Recent findings Comprehensive proteomic studies revealed a mismatch of protein abundance to their corresponding transcript abundance, which indicates that the proteome remodeling is regulated in a complex way from transcriptional control to posttranslational modifications. Key regulators in organelle clearance were also found to play critical roles in proteome remodeling. Summary These studies demonstrate that the complexity of terminal erythropoiesis is beyond the conventional transcriptomic centric perspective. Posttranslational modifications such as ubiquitination are critical in terminal erythroid proteome remodeling that is also closely coupled with organelle clearance.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalCurrent opinion in hematology
Issue number3
StatePublished - May 1 2022


  • mammalian diaphanous-related formin-2
  • organelle clearance
  • proteome remodeling
  • terminal erythropoiesis
  • ubiquitination-proteosome system

ASJC Scopus subject areas

  • Medicine(all)


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