Proteomics meets blue biotechnology: A wealth of novelties and opportunities

Erica M. Hartmann, Emie Durighello, Olivier Pible, Balbina Nogales, Fabrizio Beltrametti, Rafael Bosch, Joseph A. Christie-Oleza, Jean Armengaud*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Blue biotechnology, in which aquatic environments provide the inspiration for various products such as food additives, aquaculture, biosensors, green chemistry, bioenergy, and pharmaceuticals, holds enormous promise. Large-scale efforts to sequence aquatic genomes and metagenomes, as well as campaigns to isolate new organisms and culture-based screenings, are helping to push the boundaries of known organisms. Mass spectrometry-based proteomics can complement 16S gene sequencing in the effort to discover new organisms of potential relevance to blue biotechnology by facilitating the rapid screening of microbial isolates and by providing in depth profiles of the proteomes and metaproteomes of marine organisms, both model cultivable isolates and, more recently, exotic non-cultivable species and communities. Proteomics has already contributed to blue biotechnology by identifying aquatic proteins with potential applications to food fermentation, the textile industry, and biomedical drug development. In this review, we discuss historical developments in blue biotechnology, the current limitations to the known marine biosphere, and the ways in which mass spectrometry can expand that knowledge. We further speculate about directions that research in blue biotechnology will take given current and near-future technological advancements in mass spectrometry.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalMarine Genomics
StatePublished - Oct 1 2014


  • High-throughput proteomics
  • Metaproteomics
  • Next-generation sequencing
  • Non-model organisms
  • Proteogenomics
  • Screening

ASJC Scopus subject areas

  • Aquatic Science
  • Genetics


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