Prothrombotic effects of angiotensin

Nancy J. Brown*, Douglas E. Vaughan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


In vitro and in vivo data provide compelling evidence for an interaction between the RAS and thrombosis. Furthermore, angiotensin and AT 1 receptor blockers may influence platelet function. ACE is strategically poised to regulate these interactions. ACE catalyzes the conversion of Ang I to Ang II, which in turn stimulates the production of PAI-I, sensitizes platelets, promotes the production of superoxide radicals that scavenge free NO, and induces the expression of tissue factor. Conversely, ACE catalyzes the breakdown of bradykinin, a potent stimulus to t-PA secretion. These data suggest that clinical, genetic, or environmental factors (such as salt intake and medications) that alter ACE activity and Ang II production would be expected to impact on clotting and fibrinolytic mechanisms.

Original languageEnglish (US)
Pages (from-to)419-429
Number of pages11
JournalAdvances in Internal Medicine
StatePublished - Dec 1 2000

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'Prothrombotic effects of angiotensin'. Together they form a unique fingerprint.

Cite this