TY - JOUR
T1 - Proton magnetic resonance imaging of diffusion of high- and low-molecular-weight contrast agents in opaque porous media saturated with water
AU - Osuga, T.
AU - Han, S.
N1 - Funding Information:
We acknowledge Dr. P.T. Callaghan, Professor Emeritus at Massey University in New Zealand for the use of the MRI laboratory and for his advice in this study. This study was partly supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture.
PY - 2004/9
Y1 - 2004/9
N2 - Besides their use in contrast-enhanced proton magnetic resonance imaging (MRI), contrast agents were found to be useful as tracer molecules. Since paramagnetic ions in water have the ability to reduce the T1 of protons around them, MRI can determine the locations of Mn2+ and Gd3+ of ppm concentration in water. In opaque porous media saturated with water, MRI revealed diffusional motions of three contrast agents: MnCl 2 (molecular-weight [M.W.], 126), gadolinium-diethylene-triaminepenta acetic acid (Gd-DTPA) (M.W., 743) and albumin (Gd-DTPA) (M.W., 94,000) at a diffusional displacement ratio of 9:5:2. With the aid of these contrast agents, the transport of low- to high-molecular-weight molecules in opaque water media such as living bodies can be observed using MRI.
AB - Besides their use in contrast-enhanced proton magnetic resonance imaging (MRI), contrast agents were found to be useful as tracer molecules. Since paramagnetic ions in water have the ability to reduce the T1 of protons around them, MRI can determine the locations of Mn2+ and Gd3+ of ppm concentration in water. In opaque porous media saturated with water, MRI revealed diffusional motions of three contrast agents: MnCl 2 (molecular-weight [M.W.], 126), gadolinium-diethylene-triaminepenta acetic acid (Gd-DTPA) (M.W., 743) and albumin (Gd-DTPA) (M.W., 94,000) at a diffusional displacement ratio of 9:5:2. With the aid of these contrast agents, the transport of low- to high-molecular-weight molecules in opaque water media such as living bodies can be observed using MRI.
KW - Albumin
KW - Contrast-enhance
KW - Diffusion-contrast
KW - Gd-DTPA
KW - Paramagnetic relaxation
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U2 - 10.1016/j.mri.2003.07.004
DO - 10.1016/j.mri.2003.07.004
M3 - Article
C2 - 15288146
AN - SCOPUS:3343017535
SN - 0730-725X
VL - 22
SP - 1039
EP - 1042
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
IS - 7
ER -