Proton magnetic resonance spectroscopy (1 H-MRS) in ALS

Erik P. Pioro*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Establishing the presence of upper motor neuron (UMN) pathology is essential for an accurate and definite diagnosis of ALS. However, clinical identification of UMN dysfunction can be difficult in early disease or if lower motor neuron signs are prominent. A routine technique such as magnetic resonance imaging is usually normal and non-specific. Proton magnetic resonance spectroscopy (1 H-MRS) is a non-invasive neuroimaging technique that has successfully demonstrated evidence of neuronal abnormalities in motor regions of the brain in ALS. This review discusses the advantages and limitations of employing 1 H-MRS as an investigative tool in the diagnosis of ALS.

Original languageEnglish (US)
Pages (from-to)S7-S16
JournalAmyotrophic Lateral Sclerosis
Issue numberSUPPL. 2
StatePublished - Jun 1 2000


  • H-MRS
  • diagnosis
  • neurological disorders
  • upper motor neuron dysfunction

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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