Prox 1, a prospero-related homeobox gene expressed during mouse development

Guillermo Oliver*, Beatriz Sosa-Pineda, Sabine Geisendorf, Eric P. Spana, Chris Q. Doe, Peter Gruss

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

288 Scopus citations

Abstract

Prox 1, a likely mouse homologue of the Drosphila homeobox gene prospero has been cloned and its expression pattern analyzed during development. In Drosophila, prospero is expressed in the developing CNS, lens-secreting cone cells of the eye, and midgut. In the mouse, Prox 1 is expressed in many of the same tissues: young neurons of the subventricular region of the CNS, developing eye lens and pancreas. Expression is also detected in the developing liver and heart, as well as transiently in the skeletal muscles. The similarities in protein sequence and expression patterns between the mouse and fly cognate genes suggest that Prox 1 may play, among others, a fundamental role in early development of the murine CNS.

Original languageEnglish (US)
Pages (from-to)3-16
Number of pages14
JournalMechanisms of Development
Volume44
Issue number1
DOIs
StatePublished - Nov 1993

Keywords

  • Central nervous system
  • Drosophila
  • Eye
  • Homeobox gene
  • Muscle
  • Neuroblast
  • Pancreas
  • Prospero
  • Prox 1

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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