Prox 1, a prospero-related homeobox gene expressed during mouse development

Guillermo Oliver; Beatriz Sosa-Pineda; Sabine Geisendorf; Eric P. Spana; Chris Q. Doe; Peter Gruss

doi:10.1016/0925-4773(93)90012-M

Prox 1, a prospero-related homeobox gene expressed during mouse development

Guillermo Oliver^*, Beatriz Sosa-Pineda, Sabine Geisendorf, Eric P. Spana, Chris Q. Doe, Peter Gruss

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Article › peer-review

307 Scopus citations

Abstract

Prox 1, a likely mouse homologue of the Drosphila homeobox gene prospero has been cloned and its expression pattern analyzed during development. In Drosophila, prospero is expressed in the developing CNS, lens-secreting cone cells of the eye, and midgut. In the mouse, Prox 1 is expressed in many of the same tissues: young neurons of the subventricular region of the CNS, developing eye lens and pancreas. Expression is also detected in the developing liver and heart, as well as transiently in the skeletal muscles. The similarities in protein sequence and expression patterns between the mouse and fly cognate genes suggest that Prox 1 may play, among others, a fundamental role in early development of the murine CNS.

Original language	English (US)
Pages (from-to)	3-16
Number of pages	14
Journal	Mechanisms of Development
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/0925-4773(93)90012-M
State	Published - Nov 1993

Keywords

Central nervous system
Drosophila
Eye
Homeobox gene
Muscle
Neuroblast
Pancreas
Prospero
Prox 1

ASJC Scopus subject areas

Embryology
Developmental Biology

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10.1016/0925-4773(93)90012-M

Cite this

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title = "Prox 1, a prospero-related homeobox gene expressed during mouse development",

abstract = "Prox 1, a likely mouse homologue of the Drosphila homeobox gene prospero has been cloned and its expression pattern analyzed during development. In Drosophila, prospero is expressed in the developing CNS, lens-secreting cone cells of the eye, and midgut. In the mouse, Prox 1 is expressed in many of the same tissues: young neurons of the subventricular region of the CNS, developing eye lens and pancreas. Expression is also detected in the developing liver and heart, as well as transiently in the skeletal muscles. The similarities in protein sequence and expression patterns between the mouse and fly cognate genes suggest that Prox 1 may play, among others, a fundamental role in early development of the murine CNS.",

keywords = "Central nervous system, Drosophila, Eye, Homeobox gene, Muscle, Neuroblast, Pancreas, Prospero, Prox 1",

author = "Guillermo Oliver and Beatriz Sosa-Pineda and Sabine Geisendorf and Spana, {Eric P.} and Doe, {Chris Q.} and Peter Gruss",

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AU - Oliver, Guillermo

AU - Sosa-Pineda, Beatriz

AU - Geisendorf, Sabine

AU - Spana, Eric P.

AU - Doe, Chris Q.

AU - Gruss, Peter

PY - 1993/11

Y1 - 1993/11

N2 - Prox 1, a likely mouse homologue of the Drosphila homeobox gene prospero has been cloned and its expression pattern analyzed during development. In Drosophila, prospero is expressed in the developing CNS, lens-secreting cone cells of the eye, and midgut. In the mouse, Prox 1 is expressed in many of the same tissues: young neurons of the subventricular region of the CNS, developing eye lens and pancreas. Expression is also detected in the developing liver and heart, as well as transiently in the skeletal muscles. The similarities in protein sequence and expression patterns between the mouse and fly cognate genes suggest that Prox 1 may play, among others, a fundamental role in early development of the murine CNS.

AB - Prox 1, a likely mouse homologue of the Drosphila homeobox gene prospero has been cloned and its expression pattern analyzed during development. In Drosophila, prospero is expressed in the developing CNS, lens-secreting cone cells of the eye, and midgut. In the mouse, Prox 1 is expressed in many of the same tissues: young neurons of the subventricular region of the CNS, developing eye lens and pancreas. Expression is also detected in the developing liver and heart, as well as transiently in the skeletal muscles. The similarities in protein sequence and expression patterns between the mouse and fly cognate genes suggest that Prox 1 may play, among others, a fundamental role in early development of the murine CNS.

KW - Central nervous system

KW - Drosophila

KW - Eye

KW - Homeobox gene

KW - Muscle

KW - Neuroblast

KW - Pancreas

KW - Prospero

KW - Prox 1

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Prox 1, a prospero-related homeobox gene expressed during mouse development

Abstract

Keywords

ASJC Scopus subject areas

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