Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina

Michael A. Dyer, Frederick J. Livesey, Constance L. Cepko*, Guillermo Oliver

*Corresponding author for this work

Research output: Contribution to journalArticle

300 Scopus citations

Abstract

Retinal progenitor cells regulate their proliferation during development so that the correct number of each cell type is made at the appropriate time. We found that the homeodomain protein Prox1 regulates the exit of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. During retinogenesis, Prox1 can be detected in differentiating horizontal, bipolar and All amacrine cells. Horizontal cells are absent in retinae of Prox1-/- mice and misexpression of Prox1 in postnatal progenitor cells promotes horizontal-cell formation. Thus, Prox1 activity is both necessary and sufficient for progenitor-cell proliferation and cell-fate determination in the vertebrate retina.

Original languageEnglish (US)
Pages (from-to)53-58
Number of pages6
JournalNature Genetics
Volume34
Issue number1
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina'. Together they form a unique fingerprint.

Cite this