Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm

Zoë Burke, Guillermo Oliver

Research output: Contribution to journalArticle

107 Scopus citations

Abstract

Although important progress has been made recently in the elucidation of the molecular mechanisms that regulate differentiation and morphogenesis of endoderm-derived tissues such as pancreas and liver, less is known about the preliminary steps of early regional specification. Recent evidence supports the proposal that the early endoderm contains a bipotential precursor cell type for pancreas and liver. We have also previously shown that the activity of the homeobox gene Prox1 controls hepatocyte migration during liver morphogenesis. Using detailed comparative analysis of whole embryos and reverse transcriptase polymerase chain reaction of dissected embryonic endoderm, we have now determined that in the early endoderm, Prox1 expression is restricted to regions giving rise to the mammalian pancreas and liver. This finding indicates that Prox1 is one of the earliest specific markers of this commonly fated region of the mammalian endoderm.

Original languageEnglish (US)
Pages (from-to)147-155
Number of pages9
JournalMechanisms of Development
Volume118
Issue number1-2
DOIs
StatePublished - Oct 2002

Keywords

  • Bmp4
  • Endoderm
  • Hex
  • Hnf3 β
  • Hnf6
  • Liver
  • Mouse
  • Pancreas
  • Pdx1
  • Prox1
  • Shh

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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