TY - JOUR
T1 - Pseudoepitheliomatous hyperplasia mimicking vulvar cancer in a patient with AIDS
AU - Frimer, Marina
AU - Chudnoff, Scott
AU - Hebert, Tiffany
AU - Shahabi, Shohreh
PY - 2011/1
Y1 - 2011/1
N2 - Background: Pseudoepitheliomatous hyperplasia (PEH) clinically and histologically mimics squamous cell carcinoma (SCC), specifically in patients with HIV and AIDS. Case: A 51-year-old G3P2 with AIDS and history of vulvar cancer presented with large bilateral exophytic lesions on the vulva, grossly appearing neoplastic. Initial biopsies of the lesions were interpreted as vulvar SCC. After resolution with empiric treatment with acyclovir for possible herpes simplex virus type 2 outbreak, additional slides were reviewed, and cells with viral inclusions were identified, making the final diagnosis PEH in association with herpes simplex virus type 2 infection. Conclusions: Although PEH is infrequently encountered, PEH should be considered in the differential diagnosis of vulvar lesions. A multidisciplinary approach including the gynecologist, pathologist, and infectious disease specialists can optimize patient outcome.
AB - Background: Pseudoepitheliomatous hyperplasia (PEH) clinically and histologically mimics squamous cell carcinoma (SCC), specifically in patients with HIV and AIDS. Case: A 51-year-old G3P2 with AIDS and history of vulvar cancer presented with large bilateral exophytic lesions on the vulva, grossly appearing neoplastic. Initial biopsies of the lesions were interpreted as vulvar SCC. After resolution with empiric treatment with acyclovir for possible herpes simplex virus type 2 outbreak, additional slides were reviewed, and cells with viral inclusions were identified, making the final diagnosis PEH in association with herpes simplex virus type 2 infection. Conclusions: Although PEH is infrequently encountered, PEH should be considered in the differential diagnosis of vulvar lesions. A multidisciplinary approach including the gynecologist, pathologist, and infectious disease specialists can optimize patient outcome.
KW - AIDS
KW - HIV
KW - herpes simplex virus
KW - pseudoepitheliomatous hyperplasia
KW - vulvar cancer
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U2 - 10.1097/LGT.0b013e3181f0b8f5
DO - 10.1097/LGT.0b013e3181f0b8f5
M3 - Article
C2 - 21192180
AN - SCOPUS:78651372926
SN - 1089-2591
VL - 15
SP - 66
EP - 68
JO - Journal of lower genital tract disease
JF - Journal of lower genital tract disease
IS - 1
ER -
