TY - JOUR
T1 - Pseudomonas aeruginosa virulence and therapy
T2 - Evolving translational strategies
AU - Veesenmeyer, Jeffrey L.
AU - Hauser, Alan R.
AU - Lisboa, Thiago
AU - Rello, Jordi
PY - 2009/5
Y1 - 2009/5
N2 - Objective: Although most reviews of Pseudomonas aeruginosa therapeutics focus on antibiotics currently in use or in the pipeline, we review evolving translational strategies aimed at using virulence factor antagonists as adjunctive therapies. Data Source: Current literature regarding P. aeruginosa virulence determinants and approaches that target them, with an emphasis on type III secretion, quorum-sensing, biofilms, and flagella. Data Extraction and Synthesis: P. aeruginosa remains one of the most important pathogens in nosocomial infections, with high associated morbidity and mortality. Its predilection to develop resistance to antibiotics and expression of multiple virulence factors contributes to the frequent ineffectiveness of current therapies. Among the many P. aeruginosa virulence determinants that impact infections, type III secretion, quorum sensing, biofilm formation, and flagella have been the focus on much recent investigation. Here we review how increased understanding of these important bacterial structures and processes has enabled the development of novel approaches to inhibit each. These promising translational strategies may lead to the development of adjunctive therapies capable of improving outcomes. Conclusions: Adjuvant therapies directed against virulence factors have the potential to improve outcomes in P. aeruginosa infections.
AB - Objective: Although most reviews of Pseudomonas aeruginosa therapeutics focus on antibiotics currently in use or in the pipeline, we review evolving translational strategies aimed at using virulence factor antagonists as adjunctive therapies. Data Source: Current literature regarding P. aeruginosa virulence determinants and approaches that target them, with an emphasis on type III secretion, quorum-sensing, biofilms, and flagella. Data Extraction and Synthesis: P. aeruginosa remains one of the most important pathogens in nosocomial infections, with high associated morbidity and mortality. Its predilection to develop resistance to antibiotics and expression of multiple virulence factors contributes to the frequent ineffectiveness of current therapies. Among the many P. aeruginosa virulence determinants that impact infections, type III secretion, quorum sensing, biofilm formation, and flagella have been the focus on much recent investigation. Here we review how increased understanding of these important bacterial structures and processes has enabled the development of novel approaches to inhibit each. These promising translational strategies may lead to the development of adjunctive therapies capable of improving outcomes. Conclusions: Adjuvant therapies directed against virulence factors have the potential to improve outcomes in P. aeruginosa infections.
KW - Adjunctive therapy
KW - Biofilms
KW - Flagella
KW - Pseudomonas aeruginosa
KW - Quorum sensing
KW - Type III secretion
KW - Virulence factors
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U2 - 10.1097/CCM.0b013e31819ff137
DO - 10.1097/CCM.0b013e31819ff137
M3 - Review article
C2 - 19325463
AN - SCOPUS:67650446165
VL - 37
SP - 1777
EP - 1786
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - 5
ER -