Pseudomonas aeruginosa virulence and therapy: Evolving translational strategies

Jeffrey L. Veesenmeyer, Alan R. Hauser, Thiago Lisboa, Jordi Rello

Research output: Contribution to journalReview articlepeer-review

124 Scopus citations

Abstract

Objective: Although most reviews of Pseudomonas aeruginosa therapeutics focus on antibiotics currently in use or in the pipeline, we review evolving translational strategies aimed at using virulence factor antagonists as adjunctive therapies. Data Source: Current literature regarding P. aeruginosa virulence determinants and approaches that target them, with an emphasis on type III secretion, quorum-sensing, biofilms, and flagella. Data Extraction and Synthesis: P. aeruginosa remains one of the most important pathogens in nosocomial infections, with high associated morbidity and mortality. Its predilection to develop resistance to antibiotics and expression of multiple virulence factors contributes to the frequent ineffectiveness of current therapies. Among the many P. aeruginosa virulence determinants that impact infections, type III secretion, quorum sensing, biofilm formation, and flagella have been the focus on much recent investigation. Here we review how increased understanding of these important bacterial structures and processes has enabled the development of novel approaches to inhibit each. These promising translational strategies may lead to the development of adjunctive therapies capable of improving outcomes. Conclusions: Adjuvant therapies directed against virulence factors have the potential to improve outcomes in P. aeruginosa infections.

Original languageEnglish (US)
Pages (from-to)1777-1786
Number of pages10
JournalCritical care medicine
Volume37
Issue number5
DOIs
StatePublished - May 2009

Keywords

  • Adjunctive therapy
  • Biofilms
  • Flagella
  • Pseudomonas aeruginosa
  • Quorum sensing
  • Type III secretion
  • Virulence factors

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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