Pseudorabies virus fast axonal transport occurs by a pUS9-independent mechanism

Gina R. Daniel; Patricia J. Sollars; Gary E. Pickard; Gregory A. Smith

doi:10.1128/JVI.00771-15

Pseudorabies virus fast axonal transport occurs by a pUS9-independent mechanism

Gina R. Daniel, Patricia J. Sollars, Gary E. Pickard, Gregory A. Smith^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Reactivation from latency results in transmission of neurotropic herpesviruses from the nervous system to body surfaces, referred to as anterograde axonal trafficking. The virus-encoded protein pUS9 promotes axonal dissemination by sorting virus particles into axons, but whether it is also an effector of fast axonal transport within axons is unknown. To determine the role of pUS9 in anterograde trafficking, we analyzed the axonal transport of pseudorabies virus in the presence and absence of pUS9.

Original language	English (US)
Pages (from-to)	8088-8091
Number of pages	4
Journal	Journal of virology
Volume	89
Issue number	15
DOIs	https://doi.org/10.1128/JVI.00771-15
State	Published - 2015

ASJC Scopus subject areas

Insect Science
Virology
Microbiology
Immunology

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title = "Pseudorabies virus fast axonal transport occurs by a pUS9-independent mechanism",

abstract = "Reactivation from latency results in transmission of neurotropic herpesviruses from the nervous system to body surfaces, referred to as anterograde axonal trafficking. The virus-encoded protein pUS9 promotes axonal dissemination by sorting virus particles into axons, but whether it is also an effector of fast axonal transport within axons is unknown. To determine the role of pUS9 in anterograde trafficking, we analyzed the axonal transport of pseudorabies virus in the presence and absence of pUS9.",

author = "Daniel, {Gina R.} and Sollars, {Patricia J.} and Pickard, {Gary E.} and Smith, {Gregory A.}",

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AU - Sollars, Patricia J.

AU - Pickard, Gary E.

AU - Smith, Gregory A.

PY - 2015

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AB - Reactivation from latency results in transmission of neurotropic herpesviruses from the nervous system to body surfaces, referred to as anterograde axonal trafficking. The virus-encoded protein pUS9 promotes axonal dissemination by sorting virus particles into axons, but whether it is also an effector of fast axonal transport within axons is unknown. To determine the role of pUS9 in anterograde trafficking, we analyzed the axonal transport of pseudorabies virus in the presence and absence of pUS9.

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Pseudorabies virus fast axonal transport occurs by a pUS9-independent mechanism

Abstract

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