PSIBLAST_PairwiseStatSig: Reordering PSI-BLAST hits using pairwise statistical significance

Ankit Agrawal*, Xiaoqiu Huang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We present an add-on to BLAST and PSI-BLAST programs to reorder their hits using pairwise statistical significance. Using position-specific substitution matrices to estimate pairwise statistical significance has been recently shown to give promising results in terms of retrieval accuracy, which motivates its use to refine PSI-BLAST results, since PSI-BLAST also constructs a position-specific substitution matrix for the query sequence during the search. The obvious advantage of the approach is more accurate estimates of statistical significance because of pairwise statistical significance, along with the advantage of BLAST_PSI-BLAST in terms of speed.

Original languageEnglish (US)
Pages (from-to)1082-1083
Number of pages2
JournalBioinformatics
Volume25
Issue number8
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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