Psychiatric manifestations of olivo-ponto-cerebellar atrophy and treatment with clozapine

M. A. Parsa*, M. Simon, C. Dubrow, L. F. Ramirez, H. Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Patients with multiple system atrophy, a neurodegenerative disease entity, have a high incidence of associated mental disturbances such as a mood disorder with or without psychotic features. Treatment of the psychiatric symptoms, without compromising neurological status, is often complicated and unsuccessful. This article describes a patient with olivo-ponto-cerebellar atrophy and treatment-resistant psychotic depression whose psychiatric symptoms were successfully treated with clozapine without aggravating the neurological disabilities.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalInternational Journal of Psychiatry in Medicine
Issue number2
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Psychiatry and Mental health


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