Psychiatric symptoms in adults with phenylketonuria

Deborah A. Bilder; Barbara K. Burton; Hilary Coon; Lauren Leviton; James Ashworth; Bridget D. Lundy; Hazel Vespa; Amanda V. Bakian; Nicola Longo

doi:10.1016/j.ymgme.2012.12.006

Psychiatric symptoms in adults with phenylketonuria

Deborah A. Bilder^*, Barbara K. Burton, Hilary Coon, Lauren Leviton, James Ashworth, Bridget D. Lundy, Hazel Vespa, Amanda V. Bakian, Nicola Longo

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Background: The objective of this study was to identify psychiatric symptom patterns reported by individuals with phenylketonuria (PKU) in the outpatient clinic setting. Methods: Brief Symptom Inventory (BSI) results, phenylalanine (phe) levels, and demographic information were collected through a retrospective chart review on 64 participants in the study, "A Diversified Approach for PKU Treatment" (ADAPT). Results: The number of BSI scores meeting clinical threshold was significantly elevated for all global indexes and 6 out of 7 symptom subscales in patients with PKU. Recent and mean phe levels were correlated with age at the time of screening (R²=0.10, R²=0.10, respectively; p<0.05). Psychoticism and the Positive Symptom Distress Index (PSDI) scores were associated with metabolic control. Conclusions: The results of this study demonstrate a positive correlation between phe levels and psychiatric symptom severity in individuals with PKU.

Original language	English (US)
Pages (from-to)	155-160
Number of pages	6
Journal	Molecular Genetics and Metabolism
Volume	108
Issue number	3
DOIs	https://doi.org/10.1016/j.ymgme.2012.12.006
State	Published - Mar 2013

Funding

The ADAPT study, data collection and editorial assistance was funded by an unrestricted grant from BioMarin Pharmaceutical Inc . Editorial assistance was provided by Judy Wiles and Nicolette Blase of Facet Communications Inc. Data collection assistance was provided by Symbiotix.

Keywords

Assessment
Chronic illness
Phenylketonuria
Psychiatric
Psychosis

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology
Genetics
Endocrinology

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10.1016/j.ymgme.2012.12.006

Cite this

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title = "Psychiatric symptoms in adults with phenylketonuria",

abstract = "Background: The objective of this study was to identify psychiatric symptom patterns reported by individuals with phenylketonuria (PKU) in the outpatient clinic setting. Methods: Brief Symptom Inventory (BSI) results, phenylalanine (phe) levels, and demographic information were collected through a retrospective chart review on 64 participants in the study, {"}A Diversified Approach for PKU Treatment{"} (ADAPT). Results: The number of BSI scores meeting clinical threshold was significantly elevated for all global indexes and 6 out of 7 symptom subscales in patients with PKU. Recent and mean phe levels were correlated with age at the time of screening (R2=0.10, R2=0.10, respectively; p<0.05). Psychoticism and the Positive Symptom Distress Index (PSDI) scores were associated with metabolic control. Conclusions: The results of this study demonstrate a positive correlation between phe levels and psychiatric symptom severity in individuals with PKU.",

keywords = "Assessment, Chronic illness, Phenylketonuria, Psychiatric, Psychosis",

author = "Bilder, \{Deborah A.\} and Burton, \{Barbara K.\} and Hilary Coon and Lauren Leviton and James Ashworth and Lundy, \{Bridget D.\} and Hazel Vespa and Bakian, \{Amanda V.\} and Nicola Longo",

note = "Funding Information: The ADAPT study, data collection and editorial assistance was funded by an unrestricted grant from BioMarin Pharmaceutical Inc . Editorial assistance was provided by Judy Wiles and Nicolette Blase of Facet Communications Inc. Data collection assistance was provided by Symbiotix.",

year = "2013",

month = mar,

doi = "10.1016/j.ymgme.2012.12.006",

language = "English (US)",

volume = "108",

pages = "155--160",

journal = "Molecular Genetics and Metabolism",

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T1 - Psychiatric symptoms in adults with phenylketonuria

AU - Bilder, Deborah A.

AU - Burton, Barbara K.

AU - Coon, Hilary

AU - Leviton, Lauren

AU - Ashworth, James

AU - Lundy, Bridget D.

AU - Vespa, Hazel

AU - Bakian, Amanda V.

AU - Longo, Nicola

N1 - Funding Information: The ADAPT study, data collection and editorial assistance was funded by an unrestricted grant from BioMarin Pharmaceutical Inc . Editorial assistance was provided by Judy Wiles and Nicolette Blase of Facet Communications Inc. Data collection assistance was provided by Symbiotix.

PY - 2013/3

Y1 - 2013/3

N2 - Background: The objective of this study was to identify psychiatric symptom patterns reported by individuals with phenylketonuria (PKU) in the outpatient clinic setting. Methods: Brief Symptom Inventory (BSI) results, phenylalanine (phe) levels, and demographic information were collected through a retrospective chart review on 64 participants in the study, "A Diversified Approach for PKU Treatment" (ADAPT). Results: The number of BSI scores meeting clinical threshold was significantly elevated for all global indexes and 6 out of 7 symptom subscales in patients with PKU. Recent and mean phe levels were correlated with age at the time of screening (R2=0.10, R2=0.10, respectively; p<0.05). Psychoticism and the Positive Symptom Distress Index (PSDI) scores were associated with metabolic control. Conclusions: The results of this study demonstrate a positive correlation between phe levels and psychiatric symptom severity in individuals with PKU.

AB - Background: The objective of this study was to identify psychiatric symptom patterns reported by individuals with phenylketonuria (PKU) in the outpatient clinic setting. Methods: Brief Symptom Inventory (BSI) results, phenylalanine (phe) levels, and demographic information were collected through a retrospective chart review on 64 participants in the study, "A Diversified Approach for PKU Treatment" (ADAPT). Results: The number of BSI scores meeting clinical threshold was significantly elevated for all global indexes and 6 out of 7 symptom subscales in patients with PKU. Recent and mean phe levels were correlated with age at the time of screening (R2=0.10, R2=0.10, respectively; p<0.05). Psychoticism and the Positive Symptom Distress Index (PSDI) scores were associated with metabolic control. Conclusions: The results of this study demonstrate a positive correlation between phe levels and psychiatric symptom severity in individuals with PKU.

KW - Assessment

KW - Chronic illness

KW - Phenylketonuria

KW - Psychiatric

KW - Psychosis

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Psychiatric symptoms in adults with phenylketonuria

Abstract

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Keywords

ASJC Scopus subject areas

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