Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats

Min Zhao; Jianbo Chen; Wanyin Wang; Lei Wang; Long Ma; Hui Shen; Min Li

doi:10.1016/j.bbrc.2008.05.166

Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats

Min Zhao, Jianbo Chen, Wanyin Wang, Lei Wang, Long Ma, Hui Shen, Min Li^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Anemia is a widespread public health problem. The psychological stress decreases serum iron level and inhibits erythropoiesis. However, the molecular mechanisms involved, leading to iron mal-regulation are not well known. We used a communication box paradigm to induce psychological stress and found that serum iron level decreased after 3 d while liver iron storage increased after 7 d. Moreover, psychological stress up-regulated expressions of interleukin-6 (IL-6) and hepcidin, while down-regulating ferroportin expression after 3 d. These changes were blocked by the injection of IL-6 monoclonal antibody. In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage.

Original language	English (US)
Pages (from-to)	90-93
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	373
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2008.05.166
State	Published - Aug 15 2008

Keywords

Hepcidin
Hypoferremia
Interleukin-6
Iron
Psychological stress

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2008.05.166

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@article{6978e7e1f3124d8191d4defcc497ebde,

title = "Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats",

abstract = "Anemia is a widespread public health problem. The psychological stress decreases serum iron level and inhibits erythropoiesis. However, the molecular mechanisms involved, leading to iron mal-regulation are not well known. We used a communication box paradigm to induce psychological stress and found that serum iron level decreased after 3 d while liver iron storage increased after 7 d. Moreover, psychological stress up-regulated expressions of interleukin-6 (IL-6) and hepcidin, while down-regulating ferroportin expression after 3 d. These changes were blocked by the injection of IL-6 monoclonal antibody. In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage.",

keywords = "Hepcidin, Hypoferremia, Interleukin-6, Iron, Psychological stress",

author = "Min Zhao and Jianbo Chen and Wanyin Wang and Lei Wang and Long Ma and Hui Shen and Min Li",

note = "Funding Information: This work was supported by the Danone Nutrition Research Center of France and the National Natural Science Foundation of China (C030271675).",

year = "2008",

month = aug,

day = "15",

doi = "10.1016/j.bbrc.2008.05.166",

language = "English (US)",

volume = "373",

pages = "90--93",

journal = "Biochemical and Biophysical Research Communications",

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T1 - Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats

AU - Zhao, Min

AU - Chen, Jianbo

AU - Wang, Wanyin

AU - Wang, Lei

AU - Ma, Long

AU - Shen, Hui

AU - Li, Min

N1 - Funding Information: This work was supported by the Danone Nutrition Research Center of France and the National Natural Science Foundation of China (C030271675).

PY - 2008/8/15

Y1 - 2008/8/15

N2 - Anemia is a widespread public health problem. The psychological stress decreases serum iron level and inhibits erythropoiesis. However, the molecular mechanisms involved, leading to iron mal-regulation are not well known. We used a communication box paradigm to induce psychological stress and found that serum iron level decreased after 3 d while liver iron storage increased after 7 d. Moreover, psychological stress up-regulated expressions of interleukin-6 (IL-6) and hepcidin, while down-regulating ferroportin expression after 3 d. These changes were blocked by the injection of IL-6 monoclonal antibody. In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage.

AB - Anemia is a widespread public health problem. The psychological stress decreases serum iron level and inhibits erythropoiesis. However, the molecular mechanisms involved, leading to iron mal-regulation are not well known. We used a communication box paradigm to induce psychological stress and found that serum iron level decreased after 3 d while liver iron storage increased after 7 d. Moreover, psychological stress up-regulated expressions of interleukin-6 (IL-6) and hepcidin, while down-regulating ferroportin expression after 3 d. These changes were blocked by the injection of IL-6 monoclonal antibody. In conclusion, the IL-6-hepcidin axis is up-regulated by psychological stress in rats, resulting in hypoferremia and increase of hepatic iron storage.

KW - Hepcidin

KW - Hypoferremia

KW - Interleukin-6

KW - Iron

KW - Psychological stress

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JO - Biochemical and Biophysical Research Communications

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Psychological stress induces hypoferremia through the IL-6-hepcidin axis in rats

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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