Psychometric properties of a brief, clinically relevant measure of pain in patients with hepatocellular carcinoma

Zeeshan Butt*, Jin Shei Lai, Jennifer L. Beaumont, Karen Kaiser, Rajiv Mallick, David Cella, Jennifer L. Steel

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Purpose: Due to diagnosis at advanced stages, comorbidities, and the impact of treatment, patients with hepatocellular carcinoma (HCC) may experience pain. The purpose of this study was to evaluate the psychometric properties of a brief, clinically relevant measure of pain in HCC.

Methods: We conducted a secondary data analysis from four longitudinal studies of patients with HCC (total n = 304). All patients completed the FACT-Hepatobiliary (FACT-Hep) questionnaire, and 49 patients completed the Brief Pain Inventory (BPI) Interference scale. We conducted confirmatory factor analysis (CFA), Rasch modeling, and correlational analysis to assess the psychometrics of the three items on the FACT-Hep that assess HCC-relevant pain scale.

Results: Patients had an average age of 63.5 (±12.2) and were mostly male (76 %). The mean three-item pain subscale score was 8.5 ± 3.0. Seventy-four (24.3 %) patients reported no pain (score = 12). Results of a one-factor CFA supported unidimensionality of the items, and all items fit the Rasch model. An item-person map demonstrated that the three items covered all patients with non-extreme scores. Pain scores were significantly associated with baseline general health-related quality of life (FACT-General, r = 0.60, p < 0.001) and pain interference (BPI, r = −0.63, p < 0.001).

Conclusions: The three FACT-Hep pain items are unidimensional, cover the range of pain experienced by most patients with HCC, and demonstrate convergent validity. This pain subscale is, if future research demonstrates its sensitivity to change, potentially useful for HCC clinical trials.

Original languageEnglish (US)
Pages (from-to)2447-2455
Number of pages9
JournalQuality of Life Research
Volume23
Issue number9
DOIs
StatePublished - Oct 7 2014

Keywords

  • Hepatobiliary cancer
  • Hepatocellular carcinoma
  • Pain
  • Psychometrics
  • Quality of life

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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