Psychometric validation of the functional assessment of cancer therapy-brain (FACT-Br) for assessing quality of life in patients with brain metastases

Nemica Thavarajah, Gillian Bedard, Liying Zhang, David Cella, Jennifer L. Beaumont, May Tsao, Elizabeth Barnes, Cyril Danjoux, Arjun Sahgal, Hany Soliman, Edward Chow*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: This study aimed to test the reliability, psychometric, and clinical validity of the use of the Functional Assessment of Cancer Therapy-Brain (FACT-Br) in patients with brain metastases. Methods: Patients with brain metastases were interviewed using the FACT-Br (including the FACT-general) 1 week prior to treatment. All patients completed a follow-up assessment 1 month post-treatment. Patients with a good performance status and receiving stereotactic radiosurgery completed an additional 1 week follow-up assessment after the initial baseline interview to assess test-retest reliability. Results: Forty patients had complete 1 month follow-up data. Ten of these patients also completed the 1 week follow-up assessment from baseline. The median Karnofsky performance status of patients was 80 and the median age was 64 years. All subscales of the FACT-Br were found to be conceptually related (except for two correlations) using the following subscales: physical well-being (PWB), social/family well-being (SWB), emotional well-being (EWB), functional well-being (FWB), FACT-G total score, brain cancer subscale (BrC), and the FACT-Br total score. All FACT-Br scores demonstrated excellent reliability, except for the SWB scale which revealed good reliability. The FACT-Br scores showed no significant change in the quality of life (QoL) of patients from baseline to 1 month follow-up. Conclusion: The use of the combined FACT-G and FACT-Br Subscale to assess QoL specifically in patients with brain metastases has successfully undergone psychometric validation. Future clinical trials should use the FACT-G and FACT-Br Subscale to assess QoL in this patient population.

Original languageEnglish (US)
Pages (from-to)1017-1028
Number of pages12
JournalSupportive Care in Cancer
Issue number4
StatePublished - Apr 2014


  • Brain metastases
  • FACT-Br
  • FACT-G
  • Field-testing
  • Psychometric validation
  • Quality of life
  • Questionnaire

ASJC Scopus subject areas

  • Oncology


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