Psychomotor retardation, anorexia, weight loss, sleep disturbances, and loss of energy: Psychopathological correlates of hyperhaptoglobinemia during major depression

Michael Maes*, Herbert Y. Meltzer, Simon Scharpé, Wim Cooreman, Wim Uyttenbroeck, Eduard Suy, Carine Vandervorst, Joseph Calabrese, Jef Raus, Paul Cosyns

*Corresponding author for this work

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Recently, we have established that major depression is characterized by hyperhaptoglobinemia, which may be regarded as an index of an "acute" phase response in that illness. The present study investigates the psychopathological correlates of increased plasma concentrations of haptoglobin (Hp) in major depression. To this end, the authors studied the Hp levels in relation to depressive otems of the Structured Clinical Interview for DSM-III (SCID) and the Hamilton Rating Scale for Depression (HRSD) in 90 depressed subjects. There was a significant positive relationship between the SCID symptoms anorexia/weight loss, sleep, and psychomotor disorders and Hp plasma concentration. Hp plasma levels were significantly and positively correlated with overall severity of illness (HRSD). The HRSD symptom correlates of higher Hp levels were loss of interest, middle insomnia, and psychomotor retardation. Up to 31.4% of the variance in Hp plasma values could be explained by psychomotor disorders, anorexia, weight loss, middle insomnia, and less diurnal variation of mood. It is suggested that hyperhaptoglobinemia, as an index of an "acute" phase response in major depression, is related to the somatic dimension of depressive illness.

Original languageEnglish (US)
Pages (from-to)229-241
Number of pages13
JournalPsychiatry Research
Volume47
Issue number3
DOIs
StatePublished - Jun 1993

Keywords

  • Affective disorder
  • haptoglobin
  • inflammation
  • psychoneuroimmunology
  • somatic symptoms

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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