TY - JOUR
T1 - Psychopathology in the Adolescent and Young Adult Offspring of Parents with Dysthymic Disorder and Major Depressive Disorder
AU - Lizardi, Humberto
AU - Klein, Daniel N.
AU - Shankman, Stewart A
PY - 2004/3
Y1 - 2004/3
N2 - This study addressed the following question: are the adolescent and young adult offspring of parents with early-onset dysthymic disorder (DD) at increased risk for psychopathology? Participants included 41 offspring of 21 outpatients with early-onset DD, 19 offspring of nine outpatients with episodic major depressive disorder (MDD), and 32 offspring of 11 normal controls (NCs). Lifetime best-estimate diagnoses were determined for each offspring using a team consensus method. Diagnoses were derived blind to all information about the index parents. The offspring of outpatients with early-onset DD exhibited significantly higher lifetime rates of a bread range of psychiatric disorders than the offspring of NCs. In addition, the offspring of outpatients with early-onset DD exhibited significantly higher lifetime rates of DD, anxiety disorders, and phobia than the offspring of outpatients with episodic MDD. These results support the importance of early-onset DD in parents as a risk factor for psychopathology in their offspring.
AB - This study addressed the following question: are the adolescent and young adult offspring of parents with early-onset dysthymic disorder (DD) at increased risk for psychopathology? Participants included 41 offspring of 21 outpatients with early-onset DD, 19 offspring of nine outpatients with episodic major depressive disorder (MDD), and 32 offspring of 11 normal controls (NCs). Lifetime best-estimate diagnoses were determined for each offspring using a team consensus method. Diagnoses were derived blind to all information about the index parents. The offspring of outpatients with early-onset DD exhibited significantly higher lifetime rates of a bread range of psychiatric disorders than the offspring of NCs. In addition, the offspring of outpatients with early-onset DD exhibited significantly higher lifetime rates of DD, anxiety disorders, and phobia than the offspring of outpatients with episodic MDD. These results support the importance of early-onset DD in parents as a risk factor for psychopathology in their offspring.
UR - http://www.scopus.com/inward/record.url?scp=1542531957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1542531957&partnerID=8YFLogxK
U2 - 10.1097/01.nmd.0000116462.18406.8f
DO - 10.1097/01.nmd.0000116462.18406.8f
M3 - Article
C2 - 15091300
AN - SCOPUS:1542531957
SN - 0022-3018
VL - 192
SP - 193
EP - 199
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 3
ER -