Psychopathology in the Adolescent and Young Adult Offspring of Parents with Dysthymic Disorder and Major Depressive Disorder

Humberto Lizardi*, Daniel N. Klein, Stewart A Shankman

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

This study addressed the following question: are the adolescent and young adult offspring of parents with early-onset dysthymic disorder (DD) at increased risk for psychopathology? Participants included 41 offspring of 21 outpatients with early-onset DD, 19 offspring of nine outpatients with episodic major depressive disorder (MDD), and 32 offspring of 11 normal controls (NCs). Lifetime best-estimate diagnoses were determined for each offspring using a team consensus method. Diagnoses were derived blind to all information about the index parents. The offspring of outpatients with early-onset DD exhibited significantly higher lifetime rates of a bread range of psychiatric disorders than the offspring of NCs. In addition, the offspring of outpatients with early-onset DD exhibited significantly higher lifetime rates of DD, anxiety disorders, and phobia than the offspring of outpatients with episodic MDD. These results support the importance of early-onset DD in parents as a risk factor for psychopathology in their offspring.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalJournal of Nervous and Mental Disease
Volume192
Issue number3
DOIs
StatePublished - Mar 1 2004

ASJC Scopus subject areas

  • Psychiatry and Mental health

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