Pulmonary alveolar proteinosis complicating chronic myelogenous leukemia

David Green*, Prasad Dighe, Nabil O. Ali, George V. Katele

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Pulmonary alveolar proteinosis (PAP) has been reported in 5 patients with chronic myelogenous leukemia and approximately 20 patients with other hematologic malignancies. These patients have had recurrent infections, frequently by opportunistic organisms. This susceptibility suggests that they have impaired cell‐mediated immunity. In the case reported, splenectomy early in the course of illness may have contributed to the susceptibility to infection and PAP. Awareness of the possibility of pulmonary alveolar proteinosis in a patient with progressive dyspnea and unexplained pulmonary infiltrates should prompt early open lung biopsy to establish the diagnosis. Therapeutic pulmonary lavage is currently the treatment of choice.

Original languageEnglish (US)
Pages (from-to)1763-1766
Number of pages4
Issue number8
StatePublished - Oct 15 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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