Pulmonary disorders, including vocal cord dysfunction

Paul A. Greenberger*, Leslie C. Grammer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The lung is a very complex immunologic organ and responds in a variety of ways to inhaled antigens, organic or inorganic materials, infectious or saprophytic agents, fumes, and irritants. There might be airways obstruction, restriction, neither, or both accompanied by inflammatory destruction of the pulmonary interstitium, alveoli, or bronchioles. This review focuses on diseases organized by their predominant immunologic responses, either innate or acquired. Pulmonary innate immune conditions include transfusion-related acute lung injury, World Trade Center cough, and acute respiratory distress syndrome. Adaptive immunity responses involve the systemic and mucosal immune systems, activated lymphocytes, cytokines, and antibodies that produce CD4+ TH1 phenotypes, such as for tuberculosis or acute forms of hypersensitivity pneumonitis, and CD4+ TH2 phenotypes, such as for asthma, Churg-Strauss syndrome, and allergic bronchopulmonary aspergillosis.

Original languageEnglish (US)
Pages (from-to)S248-S254
JournalJournal of Allergy and Clinical Immunology
Volume125
Issue number2 SUPPL. 2
DOIs
StatePublished - Feb 2010

Keywords

  • Innate
  • acquired
  • aspergillosis
  • bronchiectasis
  • bronchopulmonary
  • eosinophilia
  • hypersensitivity
  • immunologic
  • lymphocyte
  • tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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