Pulmonary fibrosis and myositis in a child with anti-Jo-1 antibody

J. F. Chmiel, H. U. Wessel, I. N. Targoff, L. M. Pachman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


This is the first report of a child with anti-Jo-1 antibody. At 10, she had a chronic cough, wheezing, dyspnea on exertion, a combined obstructive and restrictive ventilatpry defect, and a decreased diffusion capacity compatible with alveolar fibrosis (lung biopsy). By age 12, she developed arthralgias, malar rash, frontal alopecia, Raynaud's phenomenon, and was seropositive for antinuclear antibodies, (SSA)Ro, Jo-1 and rheumatoid factor. At 16, symptomatic inflammatory myositis (elevated creatinine kinase, muscle biopsy) was documented with persistent anti-Jo-1. Her pulmonary symptoms have progressed despite appropriate therapy. Although her digits have become sausage shaped with swan neck deformities, joint pain is not frequent.

Original languageEnglish (US)
Pages (from-to)762-765
Number of pages4
JournalJournal of Rheumatology
Issue number4
StatePublished - 1995


  • Anti-Jo-1
  • Inflammatory myopathy
  • Interstitial fibrosis
  • Pediatric

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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