Pulmonary hypertension predicts mortality in infants with omphalocele

J. E. Baerg*, D. L. Thorpe, N. E. Sharp, Sandhya Rhea Ramlogan, S. M. Hutson, D. A. Goff, A. O. Hopper, S. D. St Peter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

OBJECTIVE: The objective of this study was to identify predictors of mortality in infants with omphalocele. METHODS: Medical records of infants with omphalocele born between January 1992 and June 2012, with follow-up to December 2012, were retrospectively reviewed. Survivors and non-survivors were compared. Evidence for pulmonary hypertension was sought between the second and seventh day after birth. All included infants had increased right ventricular pressures (RVP >40 mmhg) on echocardiogram on the second day of life with increased oxygen requirements, therefore, the finding of increased pressure was not considered a result of the transitional circulation. Logistic regression was used to evaluate the importance and independence of various factors. RESULTS: Of 51 infants whose records were reviewed, 13 died (25%) and 38 survived (75%). The median time to death was 34 days (range: 4 - 408 days). The median follow-up time for those who died was 1.5 years (range: 0.01-15 years) and for survivors was 2.6 years (range: 0.08-15 years). Logistic regression revealed that respiratory insufficiency at birth (OR: 14.8; 95%CI: 2.5-85.0) and pulmonary hypertension (OR: 6.4; 95%CI: 1.1-39.0) were independently associated with mortality. CONCLUSION: Respiratory insufficiency after birth and pulmonary hypertension are independent predictors of mortality in infants with omphalocele.

Original languageEnglish (US)
Pages (from-to)333-338
Number of pages6
JournalJournal of Neonatal-Perinatal Medicine
Volume8
Issue number4
DOIs
StatePublished - 2016

Keywords

  • Pulmonary hypertension
  • infant
  • omphalocele
  • respiratory insufficiency
  • ventilator

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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