Pulmonary intravascular macrophages: Their contribution to the mononuclear phagocyte system in 13 species

Joseph D. Brain*, Ramon M. Molina, Malcolm M. DeCamp, Angeline E. Warner

*Corresponding author for this work

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

The organ uptake of intravenously injected particles was examined in 13 species. All animals were injected intravenously with 198Au colloid and magnetic iron oxide particles. Vascular clearance kinetics of 198Au colloid was similar in all species. Pulmonary uptake of 198Au colloid ranged from 17 to 60% in sheep, calves, pigs, and cats but was <1.1% in monkeys, hyraxes, rabbits, guinea pigs, rats, mice, and chickens. For iron oxide particles, pulmonary uptake ranged from 80 to 99% in sheep, calves, pigs, goats, and cats and 15 to 18% in hamsters, hyraxes, and monkeys and was <10% in rabbits, chicken, mice, rats, and guinea pigs. In all species, the bulk of the remainder of particle uptake was in the liver. Pulmonary intravascular macrophages are the cellular site of lung uptake in calves, cats, pigs, goats, and sheep, whereas monocytes and neutrophils predominate in other species. Kupffer cells were the site of uptake in the liver. Our data show marked species differences in the fate of circulating particles; ruminants, pigs, and cats have extensive pulmonary localization due to phagocytosis by pulmonary intravascular macrophages.

Original languageEnglish (US)
Pages (from-to)L146-L154
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume276
Issue number1 20-1
DOIs
StatePublished - Jan 1999

Keywords

  • Iron oxide
  • Kupffer cell
  • Phagocytosis
  • Reticuloendothelial system
  • Ultrastructure

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

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