TY - JOUR
T1 - Pulmonary vasomotion and the distribution of vascular resistance in a dog lung lobe
AU - Grimm, D. J.
AU - Dawson, C. A.
AU - Hakim, T. S.
AU - Linehan, J. H.
PY - 1978
Y1 - 1978
N2 - We examined the influence of stellate ganglion stimulation, hypoxia, and the infusion of norepinephrine, PGF2α, serotonin, and histamine on the longitudinal distribution of vascular resistance and intravscular pressures in an isolated left lower lobe of the dog lung using the low-viscosity bolus technique. Sympathetic stimulation, norepinephrine, serotonin, PGF2α, and hypoxia increased total pulmonary vascular resistance by increasing the resistance, primarily on the arterial or upstream side of the volume midpoint, whereas histamine increased the resistance near the venous end of the lobar vascular bed. Hypoxia increased the volume upstream from the site of maximum resistance, suggesting that the larger lobar arteries were distended by the elevated lobar artery pressure. Sympathetic stimulation, norepinephrine, PGF2α, and serotonin, on the other hand, had little effect on the volume upstream from the maximum resistance, suggesting that these vasomotor stimuli prevented distension of the larger arteries.
AB - We examined the influence of stellate ganglion stimulation, hypoxia, and the infusion of norepinephrine, PGF2α, serotonin, and histamine on the longitudinal distribution of vascular resistance and intravscular pressures in an isolated left lower lobe of the dog lung using the low-viscosity bolus technique. Sympathetic stimulation, norepinephrine, serotonin, PGF2α, and hypoxia increased total pulmonary vascular resistance by increasing the resistance, primarily on the arterial or upstream side of the volume midpoint, whereas histamine increased the resistance near the venous end of the lobar vascular bed. Hypoxia increased the volume upstream from the site of maximum resistance, suggesting that the larger lobar arteries were distended by the elevated lobar artery pressure. Sympathetic stimulation, norepinephrine, PGF2α, and serotonin, on the other hand, had little effect on the volume upstream from the maximum resistance, suggesting that these vasomotor stimuli prevented distension of the larger arteries.
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U2 - 10.1152/jappl.1978.45.4.545
DO - 10.1152/jappl.1978.45.4.545
M3 - Article
C2 - 711571
AN - SCOPUS:0018227660
SN - 0161-7567
VL - 45
SP - 545
EP - 550
JO - Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
JF - Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
IS - 4
ER -