Pulmonary vasomotion and the distribution of vascular resistance in a dog lung lobe

D. J. Grimm, C. A. Dawson, T. S. Hakim, J. H. Linehan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We examined the influence of stellate ganglion stimulation, hypoxia, and the infusion of norepinephrine, PGF2α, serotonin, and histamine on the longitudinal distribution of vascular resistance and intravscular pressures in an isolated left lower lobe of the dog lung using the low-viscosity bolus technique. Sympathetic stimulation, norepinephrine, serotonin, PGF2α, and hypoxia increased total pulmonary vascular resistance by increasing the resistance, primarily on the arterial or upstream side of the volume midpoint, whereas histamine increased the resistance near the venous end of the lobar vascular bed. Hypoxia increased the volume upstream from the site of maximum resistance, suggesting that the larger lobar arteries were distended by the elevated lobar artery pressure. Sympathetic stimulation, norepinephrine, PGF2α, and serotonin, on the other hand, had little effect on the volume upstream from the maximum resistance, suggesting that these vasomotor stimuli prevented distension of the larger arteries.

Original languageEnglish (US)
Pages (from-to)545-550
Number of pages6
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Issue number4
StatePublished - 1978

ASJC Scopus subject areas

  • Endocrinology
  • Physiology


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