Pulsatile spinal cord surrogate for intradural neuromodulation studies

S. Wilson; M. A. Howard; J. D. Rossen; T. J. Brennan; B. D. Dalm; N. S. Dahdaleh; M. Utz; G. T. Gillies

doi:10.3109/03091902.2011.632061

Pulsatile spinal cord surrogate for intradural neuromodulation studies

S. Wilson, M. A. Howard, J. D. Rossen, T. J. Brennan, B. D. Dalm, N. S. Dahdaleh, M. Utz, G. T. Gillies^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We have designed, built and tested a novel spinal cord surrogate that mimics the low-amplitude cardiac-driven pulsations of the human spinal cord, for use in developing intradural implants to be used in a novel form of neuromodulation for the treatment of intractable pain and motor system dysfunction. The silicone surrogate has an oval cross section, 10mm major axis×6mm minor axis, and incorporates a 3mm diameter×3cm long angioplasty balloon that serves as the pulsation actuator. When pneumatically driven at 1 Hz and 1.5 atmospheres (≈ 1140mm Hg), the surrogate's diametric pulsation is ≈ 100 μm, which corresponds well to in vivo observations. The applications for this surrogate are presented and discussed.

Original language	English (US)
Pages (from-to)	22-25
Number of pages	4
Journal	Journal of Medical Engineering and Technology
Volume	36
Issue number	1
DOIs	https://doi.org/10.3109/03091902.2011.632061
State	Published - Jan 2012

Keywords

Intradural devices
Neuromodulation
Pial surface
Spinal cord
Tissue surrogates

ASJC Scopus subject areas

Biomedical Engineering

Access to Document

10.3109/03091902.2011.632061

Cite this

@article{7c9d4149a979453a8b79dd7b583c29a3,

title = "Pulsatile spinal cord surrogate for intradural neuromodulation studies",

abstract = "We have designed, built and tested a novel spinal cord surrogate that mimics the low-amplitude cardiac-driven pulsations of the human spinal cord, for use in developing intradural implants to be used in a novel form of neuromodulation for the treatment of intractable pain and motor system dysfunction. The silicone surrogate has an oval cross section, 10mm major axis×6mm minor axis, and incorporates a 3mm diameter×3cm long angioplasty balloon that serves as the pulsation actuator. When pneumatically driven at 1 Hz and 1.5 atmospheres (≈ 1140mm Hg), the surrogate's diametric pulsation is ≈ 100 μm, which corresponds well to in vivo observations. The applications for this surrogate are presented and discussed.",

keywords = "Intradural devices, Neuromodulation, Pial surface, Spinal cord, Tissue surrogates",

author = "S. Wilson and Howard, {M. A.} and Rossen, {J. D.} and Brennan, {T. J.} and Dalm, {B. D.} and Dahdaleh, {N. S.} and M. Utz and Gillies, {G. T.}",

note = "Funding Information: We thank our colleagues D. J. O{\textquoteright}Connell (Neuroventures LLC), R. S. Nelson, R. Shurig and S. Scott (Evergreen Medical Technologies LLC), and S. Sheehan (University of Iowa) for several useful discussions. This work was funded in part by the University of Iowa GIVF Seed Funds program and the University of Virginia Biomedical Innovation Fund., and also in part by the Kopf Family Foundation, Inc.",

year = "2012",

month = jan,

doi = "10.3109/03091902.2011.632061",

language = "English (US)",

volume = "36",

pages = "22--25",

journal = "Journal of Medical Engineering and Technology",

issn = "0309-1902",

publisher = "Informa Healthcare",

number = "1",

}

TY - JOUR

T1 - Pulsatile spinal cord surrogate for intradural neuromodulation studies

AU - Wilson, S.

AU - Howard, M. A.

AU - Rossen, J. D.

AU - Brennan, T. J.

AU - Dalm, B. D.

AU - Dahdaleh, N. S.

AU - Utz, M.

AU - Gillies, G. T.

N1 - Funding Information: We thank our colleagues D. J. O’Connell (Neuroventures LLC), R. S. Nelson, R. Shurig and S. Scott (Evergreen Medical Technologies LLC), and S. Sheehan (University of Iowa) for several useful discussions. This work was funded in part by the University of Iowa GIVF Seed Funds program and the University of Virginia Biomedical Innovation Fund., and also in part by the Kopf Family Foundation, Inc.

PY - 2012/1

Y1 - 2012/1

N2 - We have designed, built and tested a novel spinal cord surrogate that mimics the low-amplitude cardiac-driven pulsations of the human spinal cord, for use in developing intradural implants to be used in a novel form of neuromodulation for the treatment of intractable pain and motor system dysfunction. The silicone surrogate has an oval cross section, 10mm major axis×6mm minor axis, and incorporates a 3mm diameter×3cm long angioplasty balloon that serves as the pulsation actuator. When pneumatically driven at 1 Hz and 1.5 atmospheres (≈ 1140mm Hg), the surrogate's diametric pulsation is ≈ 100 μm, which corresponds well to in vivo observations. The applications for this surrogate are presented and discussed.

AB - We have designed, built and tested a novel spinal cord surrogate that mimics the low-amplitude cardiac-driven pulsations of the human spinal cord, for use in developing intradural implants to be used in a novel form of neuromodulation for the treatment of intractable pain and motor system dysfunction. The silicone surrogate has an oval cross section, 10mm major axis×6mm minor axis, and incorporates a 3mm diameter×3cm long angioplasty balloon that serves as the pulsation actuator. When pneumatically driven at 1 Hz and 1.5 atmospheres (≈ 1140mm Hg), the surrogate's diametric pulsation is ≈ 100 μm, which corresponds well to in vivo observations. The applications for this surrogate are presented and discussed.

KW - Intradural devices

KW - Neuromodulation

KW - Pial surface

KW - Spinal cord

KW - Tissue surrogates

UR - http://www.scopus.com/inward/record.url?scp=84455173912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84455173912&partnerID=8YFLogxK

U2 - 10.3109/03091902.2011.632061

DO - 10.3109/03091902.2011.632061

M3 - Article

C2 - 22188575

AN - SCOPUS:84455173912

SN - 0309-1902

VL - 36

SP - 22

EP - 25

JO - Journal of Medical Engineering and Technology

JF - Journal of Medical Engineering and Technology

IS - 1

ER -

Pulsatile spinal cord surrogate for intradural neuromodulation studies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this