Pumping Up the Synapse

Peter Penzes

doi:10.1016/j.neuron.2007.12.006

Pumping Up the Synapse

Peter Penzes^*

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Synchronized control of excitatory and inhibitory synapse maturation is crucial for normal brain wiring, while its dysfunction leads to neurodevelopmental disorders, including autism. A paper in this issue of Neuron identified a novel role for the KCC2 pump, also responsible for the GABAergic synapse developmental switch, in regulating spiny excitatory synapse maturation, implicating it in the coordinated maturation of inhibitory and excitatory synapses.

Original language	English (US)
Pages (from-to)	942-944
Number of pages	3
Journal	Neuron
Volume	56
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2007.12.006
State	Published - Dec 20 2007

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuron.2007.12.006

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title = "Pumping Up the Synapse",

abstract = "Synchronized control of excitatory and inhibitory synapse maturation is crucial for normal brain wiring, while its dysfunction leads to neurodevelopmental disorders, including autism. A paper in this issue of Neuron identified a novel role for the KCC2 pump, also responsible for the GABAergic synapse developmental switch, in regulating spiny excitatory synapse maturation, implicating it in the coordinated maturation of inhibitory and excitatory synapses.",

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AB - Synchronized control of excitatory and inhibitory synapse maturation is crucial for normal brain wiring, while its dysfunction leads to neurodevelopmental disorders, including autism. A paper in this issue of Neuron identified a novel role for the KCC2 pump, also responsible for the GABAergic synapse developmental switch, in regulating spiny excitatory synapse maturation, implicating it in the coordinated maturation of inhibitory and excitatory synapses.

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Pumping Up the Synapse

Abstract

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