Pushing the envelope of in situ transmission electron microscopy

Rajaprakash Ramachandramoorthy, Rodrigo Bernal, Horacio D. Espinosa*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Recent major improvements to the transmission electron microscope (TEM) including aberration-corrected electron optics, light-element-sensitive analytical instrumentation, sample environmental control, and high-speed and sensitive direct electron detectors are becoming more widely available. When these advances are combined with in situ TEM tools, such as multimodal testing based on microelectromechanical systems, key measurements and insights on nanoscale material phenomena become possible. In particular, these advances enable metrology that allows for unprecedented correlation to quantum mechanics and the predictions of atomistic models. In this Perspective, we provide a summary of recent in situ TEM research that has leveraged these new TEM capabilities as well as an outlook of the opportunities that exist in the different areas of in situ TEM experimentation. Although these advances have improved the spatial and temporal resolution of TEM, a critical analysis of the various in situ TEM fields reveals that further progress is needed to achieve the full potential of the technology.

Original languageEnglish (US)
Pages (from-to)4675-4685
Number of pages11
JournalACS nano
Issue number5
StatePublished - May 26 2015

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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