Abstract
Purpose: Pyomyositis is a rare disease in temperate climate regions and frequently has a subacute presentation. Because of this, the entity is often misdiagnosed. Patients and Methods: Two boys with acute lymphocytic leukemia (ALL) who presented with muscle pain, shortly after receiving induction chemotherapy, were evaluated. Results: Presenting physical examination and laboratory findings were unremarkable except for extremity pain and tenderness. These symptoms were initially attributed to a neurotoxic side effect of vincristine. As the children's symptoms progressed, muscle abscess formation was finally delineated by gallium and computed tomography scans, and the diagnosis of pyomyositis was made. In both cases, the invading organism was Staphylococcus aureus. Both children responded well to incision and drainage of the abscesses and antibiotic therapy. Conclusion: Four cases of pyomyositis occurring in ALL patients shortly after induction chemotherapy have now been described. We feel that when children from this population present with muscle pain, pyomyositis should be part of the differential diagnosis. With early medical and surgical intervention, morbidity and mortality can be avoided.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 323-326 |
| Number of pages | 4 |
| Journal | Journal of Pediatric Hematology/Oncology |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 10 1996 |
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Keywords
- Acute lymphocytic leukemia
- Immunocompromised host
- Pyomyositis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Oncology
- Hematology
Cite this
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Pyomyositis during induction chemotherapy for acute lymphocytic leukemia. / Corden, Timothy E.; Morgan, Elaine R.
In: Journal of Pediatric Hematology/Oncology, Vol. 18, No. 3, 10.08.1996, p. 323-326.Research output: Contribution to journal › Article
TY - JOUR
T1 - Pyomyositis during induction chemotherapy for acute lymphocytic leukemia
AU - Corden, Timothy E.
AU - Morgan, Elaine R.
PY - 1996/8/10
Y1 - 1996/8/10
N2 - Purpose: Pyomyositis is a rare disease in temperate climate regions and frequently has a subacute presentation. Because of this, the entity is often misdiagnosed. Patients and Methods: Two boys with acute lymphocytic leukemia (ALL) who presented with muscle pain, shortly after receiving induction chemotherapy, were evaluated. Results: Presenting physical examination and laboratory findings were unremarkable except for extremity pain and tenderness. These symptoms were initially attributed to a neurotoxic side effect of vincristine. As the children's symptoms progressed, muscle abscess formation was finally delineated by gallium and computed tomography scans, and the diagnosis of pyomyositis was made. In both cases, the invading organism was Staphylococcus aureus. Both children responded well to incision and drainage of the abscesses and antibiotic therapy. Conclusion: Four cases of pyomyositis occurring in ALL patients shortly after induction chemotherapy have now been described. We feel that when children from this population present with muscle pain, pyomyositis should be part of the differential diagnosis. With early medical and surgical intervention, morbidity and mortality can be avoided.
AB - Purpose: Pyomyositis is a rare disease in temperate climate regions and frequently has a subacute presentation. Because of this, the entity is often misdiagnosed. Patients and Methods: Two boys with acute lymphocytic leukemia (ALL) who presented with muscle pain, shortly after receiving induction chemotherapy, were evaluated. Results: Presenting physical examination and laboratory findings were unremarkable except for extremity pain and tenderness. These symptoms were initially attributed to a neurotoxic side effect of vincristine. As the children's symptoms progressed, muscle abscess formation was finally delineated by gallium and computed tomography scans, and the diagnosis of pyomyositis was made. In both cases, the invading organism was Staphylococcus aureus. Both children responded well to incision and drainage of the abscesses and antibiotic therapy. Conclusion: Four cases of pyomyositis occurring in ALL patients shortly after induction chemotherapy have now been described. We feel that when children from this population present with muscle pain, pyomyositis should be part of the differential diagnosis. With early medical and surgical intervention, morbidity and mortality can be avoided.
KW - Acute lymphocytic leukemia
KW - Immunocompromised host
KW - Pyomyositis
UR - http://www.scopus.com/inward/record.url?scp=0029995662&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029995662&partnerID=8YFLogxK
U2 - 10.1097/00043426-199608000-00021
DO - 10.1097/00043426-199608000-00021
M3 - Article
C2 - 8689354
AN - SCOPUS:0029995662
VL - 18
SP - 323
EP - 326
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 3
ER -