Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents

Chris V. Galliford*, Karl A. Scheidt

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

1951 Scopus citations

Abstract

The 3,3′ -pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.

Original languageEnglish (US)
Pages (from-to)8748-8758
Number of pages11
JournalAngewandte Chemie - International Edition
Volume46
Issue number46
DOIs
StatePublished - Dec 10 2007

Keywords

  • Antitumor agents
  • Medicinal chemistry
  • Natural products
  • Spirooxindoles
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint

Dive into the research topics of 'Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents'. Together they form a unique fingerprint.

Cite this