Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents

Chris V. Galliford; Karl A. Scheidt

doi:10.1002/anie.200701342

Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents

Chris V. Galliford^*, Karl A. Scheidt

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Short survey › peer-review

2110 Scopus citations

Abstract

The 3,3′ -pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.

Original language	English (US)
Pages (from-to)	8748-8758
Number of pages	11
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	46
DOIs	https://doi.org/10.1002/anie.200701342
State	Published - Dec 10 2007

Keywords

Antitumor agents
Medicinal chemistry
Natural products
Spirooxindoles
Total synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200701342

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abstract = "The 3,3′ -pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.",

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author = "Galliford, {Chris V.} and Scheidt, {Karl A.}",

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AU - Galliford, Chris V.

AU - Scheidt, Karl A.

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Y1 - 2007/12/10

N2 - The 3,3′ -pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.

AB - The 3,3′ -pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.

KW - Antitumor agents

KW - Medicinal chemistry

KW - Natural products

KW - Spirooxindoles

KW - Total synthesis

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DO - 10.1002/anie.200701342

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 46

ER -

Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents

Abstract

Keywords

ASJC Scopus subject areas

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