Abstract
The 3,3′ -pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.
Original language | English (US) |
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Pages (from-to) | 8748-8758 |
Number of pages | 11 |
Journal | Angewandte Chemie - International Edition |
Volume | 46 |
Issue number | 46 |
DOIs | |
State | Published - Dec 10 2007 |
Keywords
- Antitumor agents
- Medicinal chemistry
- Natural products
- Spirooxindoles
- Total synthesis
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)