Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents

Chris V. Galliford; Karl A. Scheidt

doi:10.1002/anie.200701342

Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents

Chris V. Galliford^*, Karl A. Scheidt

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Short survey › peer-review

2372 Scopus citations

Abstract

The 3,3′ -pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.

Original language	English (US)
Pages (from-to)	8748-8758
Number of pages	11
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	46
DOIs	https://doi.org/10.1002/anie.200701342
State	Published - 2007

Keywords

Antitumor agents
Medicinal chemistry
Natural products
Spirooxindoles
Total synthesis

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.200701342

Cite this

@article{6d853c6a7fc1470a94458886fb624df2,

title = "Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents",

abstract = "The 3,3′ -pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.",

keywords = "Antitumor agents, Medicinal chemistry, Natural products, Spirooxindoles, Total synthesis",

author = "Galliford, {Chris V.} and Scheidt, {Karl A.}",

year = "2007",

doi = "10.1002/anie.200701342",

language = "English (US)",

volume = "46",

pages = "8748--8758",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "46",

}

TY - JOUR

T1 - Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents

AU - Galliford, Chris V.

AU - Scheidt, Karl A.

PY - 2007

Y1 - 2007

N2 - The 3,3′ -pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.

AB - The 3,3′ -pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.

KW - Antitumor agents

KW - Medicinal chemistry

KW - Natural products

KW - Spirooxindoles

KW - Total synthesis

UR - http://www.scopus.com/inward/record.url?scp=36749025633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36749025633&partnerID=8YFLogxK

U2 - 10.1002/anie.200701342

DO - 10.1002/anie.200701342

M3 - Short survey

C2 - 17943924

AN - SCOPUS:36749025633

SN - 1433-7851

VL - 46

SP - 8748

EP - 8758

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 46

ER -

Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this